- Boc-DL-Pro-OMe
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- $0.00/ kg
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2026-04-30
- CAS:145681-01-2
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1T
- Boc-DL-Pro-OMe
-
- $1.00 / 1g
-
2020-01-06
- CAS:145681-01-2
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 100KG
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| | PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER Basic information |
| Product Name: | PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER | | Synonyms: | Methyl 1-Boc-2-pyrrolidinecarboxylate;1-Boc-2-pyrrolidinecarboxylic acid Methyl ester;t-BOC-L-Pro-OMe;Boc-DL-proline Methyl ester;1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-diMethylethyl) 2-Methyl ester;1-O-tert-butyl 2-O-methyl pyrrolidine-1,2-dicarboxylate;Methyl N-Boc-Pyrrolidine-2-Carboxylate;1-(1,1-Dimethylethyl) 2-methyl 1,2-pyrrolidinedicarboxylate | | CAS: | 145681-01-2 | | MF: | C11H19NO4 | | MW: | 229.27 | | EINECS: | | | Product Categories: | pharmacetical | | Mol File: | Mol File |  |
| | PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER Chemical Properties |
| Boiling point | 288.6±33.0 °C(Predicted) | | density | 1.120±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | -3.35±0.40(Predicted) | | Appearance | Colorless to light yellow Liquid |
| | PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of methyl 1-Boc-2-pyrrolidinecarboxylate from Boc-L-proline and iodomethane was as follows: potassium carbonate (K2CO3, 1.1 kg, 8.0 mol) and iodomethane (CH3I, 659 g, 4.65 mol) were added to a 1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid (500 g, 2.32 mol) in a solution of dimethylformamide (DMF, 2.5 L). The reaction mixture was stirred at room temperature for 12 h followed by filtration. The filtrate was concentrated under vacuum. The residue was dissolved in ethyl acetate (EtOAc, 2 L), washed sequentially with water (2 x 1 L) and brine (1 L), dried with magnesium sulfate (MgSO4), and finally concentrated under vacuum to afford methyl 1-Boc-2-pyrrolidinecarboxylate (417.8 g, 96% yield) as a yellow oil.1H NMR (CDCl3) data were as follows: δ 1.37 (9H m), 1.72-1.84 (3H, m), 2.15 (1H, m), 3.26-3.51 (2H, m), 3.65 (3H, s), 4.17 (1H, m). | | References | [1] Patent: WO2013/14448, 2013, A1. Location in patent: Page/Page column 103
[2] Patent: WO2016/89977, 2016, A1. Location in patent: Paragraph 00137
[3] Patent: WO2014/28675, 2014, A1. Location in patent: Page/Page column 118
[4] Patent: WO2016/138532, 2016, A1. Location in patent: Paragraph 0376
[5] Tetrahedron Asymmetry, 2003, vol. 14, # 10, p. 1323 - 1333 |
| | PYRROLIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER Preparation Products And Raw materials |
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