Peptidyl prolyl isomerase F

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Peptidyl prolyl isomerase F Basic information
Description Source Background
Product Name:Peptidyl prolyl isomerase F
Synonyms:Cyp-D;Peptidyl prolyl isomerase F;CYP-40;PPID;Cyclophilin F human;Cyclophilin D human;Peptidyl prolyl isomerase D;PPIF
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MW:0
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Mol File:Mol File
Peptidyl prolyl isomerase F Structure
Peptidyl prolyl isomerase F Chemical Properties
storage temp. -70°C
form liquid
biological sourcehuman
Safety Information
WGK Germany WGK 3
Storage Class10 - Combustible liquids
MSDS Information
Peptidyl prolyl isomerase F Usage And Synthesis
UsesHuman cyclophilin D has been used to study the effects of muscle denervation on the opening of the permeability transition pore and on the expression of cyclophilin D in rats.
Biological ActivityCyclophilin D catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerates the folding of proteins and thus their formation. It plays a decisive role in mitochondrial permeability transition. The protein can bind to the immunosuppressant cyclosporine A and its overexpression suppresses the apoptosis in cancer cells.
DescriptionCyclophilin-D Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 178 amino acids and having a molecular mass of 18.9kDa.
The Cyclophilin-D is purified by proprietary chromatographic techniques.
SourceEscherichia Coli
BackgroundCyclophilin-D is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and speeds up the protein folding. Cyclophilin-D possess PPIase activity and binds to the immunosuppressant cyclosporin-A. Cyclophilin-D is very well known that its overexpression suppresses the apoptosis in cancer cell. Cyclophilin-D suppresses apoptotic cell death by the use of mitochondrial hexokinase-2 dependent mechanism in cancer cells.
Peptidyl prolyl isomerase F Preparation Products And Raw materials
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