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N-Methylhomopiperazine

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CAS:4318-37-0
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CAS:4318-37-0
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N-Methylhomopiperazine manufacturers

N-Methylhomopiperazine Basic information
Product Name:N-Methylhomopiperazine
Synonyms:1H-1,4-Diazepine, hexahydro-1-methyl-;1-METHYLHOMOPIPERAZINE;1-METHYL-1,4-DIAZEPANE;1-METHYL-1,4-PERHYDRODIAZEPINE;HEXAHYDRO-1-METHYL-1H-1,4-DIAZEPINE;N-METHYLHOMOPIPERAZINE;MHPRZ;N-METHYL-1,4-DIAZACYCLOHEPTANE
CAS:4318-37-0
MF:C6H14N2
MW:114.19
EINECS:629-362-3
Product Categories:Amines and Anilines;Heterocycles;1
Mol File:4318-37-0.mol
N-Methylhomopiperazine Structure
N-Methylhomopiperazine Chemical Properties
Boiling point 74-75 °C/35 mmHg (lit.)
density 0.918 g/mL at 25 °C (lit.)
refractive index n20/D 1.477(lit.)
Fp 113 °F
storage temp. -20°C
pka10.82±0.20(Predicted)
form liquid
AppearanceColorless to light yellow Liquid
InChIInChI=1S/C6H14N2/c1-8-5-2-3-7-4-6-8/h7H,2-6H2,1H3
InChIKeyFXHRAKUEZPSMLJ-UHFFFAOYSA-N
SMILESN1(C)CCCNCC1
CAS DataBase Reference4318-37-0(CAS DataBase Reference)
NIST Chemistry ReferenceN-methyl homopiperazine(4318-37-0)
Safety Information
Hazard Codes C
Risk Statements 10-22-34
Safety Statements 16-26-27-36/37/39-45
RIDADR UN 2920 8/PG 2
WGK Germany 3
HazardClass 4.1
PackingGroup II
HS Code 29339900
Storage Class3 - Flammable liquids
Hazard ClassificationsAcute Tox. 4 Oral
Flam. Liq. 3
Skin Corr. 1B
MSDS Information
ProviderLanguage
Hexahydro-1-methyl-1H-1,4-diazepine English
SigmaAldrich English
N-Methylhomopiperazine Usage And Synthesis
Chemical PropertiesColorless liquid
Uses1-Methylhomopiperazine was used in the synthesis of:
  • novel benzimidazole derivatives having pharmacological activities
  • platinum(II) substituted disulfide complexes
General Description1-Methylhomopiperazine undergoes coupling reaction with a series of diazonium salts to afford the 4-methyl-1-[2-aryl-1-diazenyl]-1,4-diazepanes.
Synthesis

(1) N-(2-haloethyl)trifluoroacetamide was prepared by reacting with ethyl trifluoroacetate in the presence of a solvent and a catalyst using a 2-haloethylamine compound as an initial raw material;

(2) N-(2-haloethyl)trifluoroacetamide obtained in step (1) was prepared by reacting with methylamine or methylamine hydrochloride in the presence of a solvent and a catalyst to obtain N-methyl-N'-trifluoroacetylethylenediamine;

(3) taking N-methyl-N'-trifluoroacetylethylenediamine obtained in step (2) as raw material, reacting with 1,3-disubstituted propane compounds under the action of a solvent and a catalyst to prepare N-methyl-N '-trifluoroacetylhomopiperazine;

(4) using N-methyl-N'-trifluoroacetylhomopiperazine obtained in step (3) as raw material, reacting with hydrogen chloride ethanol solution to prepare to obtain N-methylhomopiperazine dihydrochloride and recovering ethyl trifluoroacetate;

(5) using N-methylhomopiperazine obtained in step (4) as raw material, reacting with 1,3-disubstituted propane compound under the effect of solvent and catalyst to prepare to obtain N-methylhomopiperazine dihydrochloride;

(5) using N-methylhomopiperazine dihydrochloride obtained in step (4) was used as raw material, and N-methylhomopiperazine was prepared by alkalization under the action of solvent and catalyst.

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