| Company Name: |
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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| Tel: |
025-66113011 17714375163 |
| Email: |
cfzhang@aikonchem.com |
| Products Intro: |
Product Name:1-(chloromethyl)-4-aza-1-azonia bicyclo[2.2.2]octane chloride
CAS:36273-11-7
Purity:95% Package:1g;5g;10g
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| Company Name: |
Bide Pharmatech Ltd.
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| Tel: |
400-400-164-7117 18317119277 |
| Email: |
product02@bidepharm.com |
| Products Intro: |
Product Name:1-(Chloromethyl)-1,4-diazabicyclo[2.2.2]octan-1-ium chloride
CAS:36273-11-7
Purity:97% Package:100mg;250mg;1g;5g Remarks:BD628574
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| Company Name: |
DebyeTec.com Inc.
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| Tel: |
18086626237 18086626237 |
| Email: |
2693528373@qq.com |
| Products Intro: |
Product Name:4-Aza-1-azoniabicyclo[2.2.2]octane,1-(chloromethyl)-,chloride(1:1)
CAS:36273-11-7
Purity:95+% Package:1g;25g;100g;1kg;
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| | 1-(chloromethyl)-4-aza-1-azonia bicyclo[2.2.2]octane chloride Basic information |
| | 1-(chloromethyl)-4-aza-1-azonia bicyclo[2.2.2]octane chloride Chemical Properties |
| | 1-(chloromethyl)-4-aza-1-azonia bicyclo[2.2.2]octane chloride Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 1-(chloromethyl)-1,4-diazabicyclo[2.2.2]octan-1-ium chloride from triethylenediamine (DABCO) and dichloromethane: 1,4-diazabicyclo[2.2.2]octane (DABCO) (11.2 g, 0.1 mol) was dissolved in 30 mL of dichloromethane, and the reaction mixture was stirred under reflux conditions overnight. Upon completion of the reaction, a white solid was obtained by filtration, washed with dichloromethane (2 x 20 mL) and dried under vacuum to afford 1-(chloromethyl)-1,4-diazabicyclo[2.2.2]octan-1-ium chloride in 96% (18.7 g) yield. The product 1-(chloromethyl)-1,4-diazabicyclo[2.2.2]octan-1-ium chloride was characterized as follows: 1H-NMR (500 MHz, D2O) δ 4.97 (s, 2H), 3.40 (t, J = 7.0 Hz, 6H), 3.10 (t, J = 7.5 Hz, 6H); 13C-NMR (125 MHz, D2O) δ 68.2, 51.1, 43.9. | | References | [1] Tetrahedron Letters, 2014, vol. 55, # 49, p. 6643 - 6646
[2] Journal of Organic Chemistry, 2017, vol. 82, # 22, p. 11792 - 11798
[3] Journal of Fluorine Chemistry, 1996, vol. 81, # 1, p. 43 - 50
[4] Chinese Journal of Chemistry, 2015, vol. 33, # 2, p. 220 - 224
[5] Patent: WO2014/68341, 2014, A2. Location in patent: Page/Page column 39 |
| | 1-(chloromethyl)-4-aza-1-azonia bicyclo[2.2.2]octane chloride Preparation Products And Raw materials |
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