|
|
| | THP-SS-alcohol Basic information |
| Product Name: | THP-SS-alcohol | | Synonyms: | THP-SS-alcohol;Ethanol, 2-[[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethyl]dithio]-;2-((2-((Tetrahydro-2H-pyran-2-yl)oxy)ethyl)disulfaneyl)ethan-1-ol | | CAS: | 877864-04-5 | | MF: | C9H18O3S2 | | MW: | 238.37 | | EINECS: | | | Product Categories: | | | Mol File: | 877864-04-5.mol |  |
| | THP-SS-alcohol Chemical Properties |
| | THP-SS-alcohol Usage And Synthesis |
| Description | THP-SS-alcohol is a cleavable linker contains a THP alcohol protecting group and a disulfide bond. The disulfide bonds can be cleaved by using Dithiothreitol (DTT) reagent. The THP protecting group can be removed under acidic conditions. | | Uses | THP-SS-alcohol is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | | IC 50 | Disulfide Cleavable Linker; Cleavable Linker | | References | [1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268 |
| | THP-SS-alcohol Preparation Products And Raw materials |
|