| Company Name: |
Pharmacodia (Beijing) Co.,Ltd
|
| Tel: |
+86-400-851-9921 |
| Email: |
sales@pharmacodia.com |
| Products Intro: |
Product Name:TSI-01
CAS:704878-75-1
Package:10Mg-100g
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TSI-01 manufacturers
- TSI-01
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- $74.00 / 1mg
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2026-01-30
- CAS:704878-75-1
- Min. Order:
- Purity: 99.87%
- Supply Ability: 10g
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| Product Name: | TSI-01 | | Synonyms: | TSI-01;isopropyl 4-(3,4-dichloro-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)benzoate;Benzoic acid, 4-(3,4-dichloro-2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-, 1-methylethyl ester | | CAS: | 704878-75-1 | | MF: | C14H11Cl2NO4 | | MW: | 328.15 | | EINECS: | | | Product Categories: | | | Mol File: | 704878-75-1.mol |  |
| | TSI-01 Chemical Properties |
| Melting point | 150-152°C | | storage temp. | Amber Vial, -20°C Freezer, Under inert atmosphere | | solubility | DMSO (Slightly), Ethyl Acetate (Slightly) | | form | Solid | | color | Light Yellow |
| | TSI-01 Usage And Synthesis |
| Description | Platelet-activating factor (PAF) is a pro-inflammatory phospholipid mediator that is rapidly synthesized by lyso-PAF acetyltransferase (lyso-PAFAT) in response to extracellular stimuli. Two types of lyso-PAFAT have been identified: lysophosphatidylcholine acyltransferase (LPCAT)1, which is mostly expressed in the lungs, and LPCAT2, which is expressed in inflammatory cells. TSI-01 is a selective inhibitor of LPCAT2 (IC50s = 0.47 versus 3.02 μM for human LPCAT2 and LPCAT1, respectively). At 60 μM it was shown to suppress PAF biosynthesis in mouse peritoneal macrophages stimulated with a calcium ionophore. | | Uses | TSI-01 is a selectve inhibitor of LPCAT2, a platelet-activiating factor acetyltransferase (PAFAT) which acts as a pro-inflammatory phospholipid mediator. Inhibition leads to suppression of PAF biosynthesis. | | References | [1] MEGUMI TARUI. Selective inhibitors of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2.[J]. Journal of Lipid Research, 2014, 55 7: 1386-1396. DOI: 10.1194/jlr.m049205 |
| | TSI-01 Preparation Products And Raw materials |
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