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2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)-
manufacturers
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| | 2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)-
Basic information |
| Product Name: | 2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)-
| | Synonyms: | 2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)-;4-(5-bromo-1H-indol-3-yl)pyrimidin-2-amine;Benzoicacid,5-acetyl-3-hydroxy-,methylester;2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)-, 10 mM in DMSO;Meridianin C | | CAS: | 213473-00-8 | | MF: | C12H9BrN4 | | MW: | 289.13 | | EINECS: | | | Product Categories: | | | Mol File: | 213473-00-8.mol |  |
| | 2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)-
Chemical Properties |
| Melting point | 103-106 °C | | Boiling point | 594.4±60.0 °C(Predicted) | | density | 1.680±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | pka | 14.31±0.30(Predicted) |
| | 2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)-
Usage And Synthesis |
| Uses | Meridianin C is a marine natural product with anticancer activity. Meridianin C has significant inhibitory effects on four different human tongue cancer cells (YD-8, YD-10B, YD-38 and HSC-3). Meridianin C most strongly reduced the growth of YD-10B cells, the most aggressive and tumorigenic of the cell lines tested. Meridianin C also induced significant accumulation of large vesicles in YD-10B cells, validating its function through macrophagocytosis. Meridianin C reduces cellular levels of Dickkopf-related protein-3 (DKK-3), a known negative regulator of macrophagy. Meridianin C affects macrophagocytosis by downregulating DKK-3, thereby affecting cell proliferation[1]. | | References | [1] Meridianin C inhibits the growth of YD-10B human tongue cancer cells through macropinocytosis and the down-regulation of Dickkopf-related protein-3 |
| | 2-Pyrimidinamine, 4-(5-bromo-1H-indol-3-yl)-
Preparation Products And Raw materials |
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