- LB100
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- $48.00
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2026-07-27
- CAS:1632032-53-1
- Purity: 99.93%
- Supply Ability: 10g
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| Product Name: | LB-100 | | Synonyms: | endothall 4-methylpiperazine monoamide;LB-100;LB 100;LB100;LB-100
(LB100);7-Oxabicyclo[2.2.1]heptane-2-carboxylic acid, 3-[(4-methyl-1-piperazinyl)carbonyl]-, (1R,4S)-rel-;LB-100 (1R,4S);rel-(1R,4S)-3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid;LB-100（b）;(1r,4s)-3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid | | CAS: | 1632032-53-1 | | MF: | C13H20N2O4 | | MW: | 268.31 | | EINECS: | | | Product Categories: | | | Mol File: | 1632032-53-1.mol |  |
| | LB-100 Chemical Properties |
| Boiling point | 486.9±45.0 °C(Predicted) | | density | 1.312±0.06 g/cm3(Predicted) | | storage temp. | Store at -20 °C | | solubility | DMSO:54.0(Max Conc. mg/mL);201.26(Max Conc. mM) | | form | A crystalline solid | | pka | 4.03±0.40(Predicted) | | color | White to off-white |
| | LB-100 Usage And Synthesis |
| Uses | LB-100 is a small molecule inhibitor of protein phosphatase 2A with potent chemo- and radio-sensitizing potential in variety of cancer types including pancreatic cancer and colorectal cancer of human and animal model. | | in vivo | LB-100 (2 mg/kg, i.p.) decreases in a time-dependent manner the activity of PP2A in xenografts and livers in nude mice. LB-100 does not alter the expression of the three PP2A subunits (PP2A_A, PP2A_B, and PP2A_C) in cell lines, xenografts, or livers, as confirmed by immunoblotting. The combination of doxorubicin (1.5 kg/mL, every other day) and LB-100 (2 mg/kg, every other day) significantly slows the growth of tumors with reduction of tumor volume in two animals with no effects on tumor growth in animals treated with single agents[2]. |
| | LB-100 Preparation Products And Raw materials |
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