N-苯基-7-(羟基亚胺基)环丙烯并[B]苯并吡喃-1A-甲酰胺 CAS#: 179068-02-1

N-苯基-7-(羟基亚胺基)环丙烯并[B]苯并吡喃-1A-甲酰胺

中文名称	N-苯基-7-(羟基亚胺基)环丙烯并[B]苯并吡喃-1A-甲酰胺
中文同义词	N-苯基-7-(羟基亚胺基)环丙烯并[B]苯并吡喃-1A-甲酰胺;化合物PHCCC;PHCCC游离态;7-(肟基)-N-苯基-7,7A-二氢环丙烷[B]苯并哌喃-1A(1H)-酰胺;PHCCC,MGLU 4的变构增强剂;PHCCC,ALLOSTERIC POTENTIATOR AT MGLU4;化合物PHCCC,10 MM DMSO 溶液
英文名称	PHCCC
英文同义词	7,7a-Dihydro-7-(hydroxyimino)-N-phenylbenzo[b]cyclopropa[e]pyran-1a(1H)-carboxamide;Benzo[b]cyclopropa[e]pyran-1a(1H)-carboxamide, 7,7a-dihydro-7-(hydroxyimino)-N-phenyl-;PHCCC >=97% (HPLC);Cyclopropa[b][1]benzopyran-1a(1H)-carboxamide,7,7a-dihydro-7-(hydroxyimino)-N-phenyl-,(7Z)-;(7Z)-7-hydroxyimino-N-phenyl-1,7a-dihydrocyclopropa[b]chromene-1a-carboxamide;(-) PHCCC;7-(Hydroxyimino)-N-phenyl-7,7a-dihydrocyclopropa[b]chromene-1a(1H)-carboxamide;allosteric,disease,Metabotropic glutamate receptors,Inhibitor,PHCCC,neurons,neuroprotective,mGluR,Parkinson's,inhibit
CAS号	179068-02-1
分子式	C17H14N2O3
分子量	294.3
EINECS号
相关类别
Mol文件	179068-02-1.mol
结构式

储存条件	under inert gas (nitrogen or Argon) at 2-8°C
溶解度	溶于二甲基亚砜
形态	粉末
颜色	白色至米白色
InChI	1S/C17H14N2O3/c20-16(18-11-6-2-1-3-7-11)17-10-13(17)15(19-21)12-8-4-5-9-14(12)22-17/h1-9,13,21H,10H2,(H,18,20)/b19-15+
InChIKey	FPXPIEZPAXSELW-XDJHFCHBSA-N
SMILES	O=C(NC1=CC=CC=C1)C2(C/3C2)OC4=C(C=CC=C4)C3=N/O

PHCCC 是一种 I 型 mGluR (Group I mGluR) 拮抗剂，IC50 为 3 μM，PHCCC 也是 mGlu4 受体选择性正向调节剂。具有抗帕金森病作用。

Group I mGluR receptors

3 μM (IC ₅₀ )

PHCCC potentiated the effect of L-(+)-2-amino-4-phosphonobutyric acid (L-AP4) in inhibiting transmission at the striatopallidal synapse.

PHCCC (75 nmol/2.5 μl; intracerebroventricular) produces an antiparkinsonian effect in a dopamine depletion akinesia model.