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| | 4-(2-methyl-1H-imidazol-1-yl)-2,2-diphenylbutanamide hydrochloride Basic information |
| | 4-(2-methyl-1H-imidazol-1-yl)-2,2-diphenylbutanamide hydrochloride Chemical Properties |
| storage temp. | 2-8°C | | solubility | H2O: soluble15mg/mL, clear | | form | powder | | color | white to beige | | Water Solubility | H2O: 15mg/mL, clear | | InChIKey | SQKXYSGRELMAAU-UHFFFAOYSA-N | | SMILES | [n]3(c(ncc3)C)CCC(c2ccccc2)(c1ccccc1)C(=O)N |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | 4-(2-methyl-1H-imidazol-1-yl)-2,2-diphenylbutanamide hydrochloride Usage And Synthesis |
| Uses | Imidafenacin hydrochloride is a potent and selective inhibitor of M3 receptors with a Kb of 0.317 nM[1]. | | Biological Activity | Imidafenacin exhibits anticholinergic properties. It also has potential therapeutic effects on prostatic hyperplasia.', 'Imidafenacin is a potent antimuscarinic agent th at exhibits selectivity toward muscarinic M3 receptors with Kb of 0.317 nM. Imidafenacin is used for treating overactive bladder. | | References | [1] Miyachi H, et al. Synthesis and antimuscarinic activity of a series of 4-(1-Imidazolyl)-2,2-diphenylbutyramides: discovery of potent and subtype-selective antimuscarinic agents. Bioorg Med Chem. 1999 Jun;7(6):1151-61. DOI:10.1016/s0968-0896(99)00003-6
[2] Yamazaki T, et al. Imidafenacin has no influence on learning in nucleus basalis of Meynert-lesioned rats. Naunyn Schmiedebergs Arch Pharmacol. 2013 Dec;386(12):1095-102. DOI:10.1007/s00210-013-0910-z |
| | 4-(2-methyl-1H-imidazol-1-yl)-2,2-diphenylbutanamide hydrochloride Preparation Products And Raw materials |
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