- GSK6853
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- $35.00 / 5mg
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2026-04-22
- CAS:1910124-24-1
- Min. Order:
- Purity: 99.00%
- Supply Ability: 10g
- GSK6853
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- $1.00 / 1KG
-
2019-12-26
- CAS:1910124-24-1
- Min. Order: 1KG
- Purity: 97%-99.9%
- Supply Ability: 100kg
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| | GSK6853 Basic information | | Uses |
| Product Name: | GSK6853 | | Synonyms: | GSK6853;GSK-6853;GSK 6853;BRPF1 bromodomain inhibitor GS6853;CS-2243;N-[2,3-dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-2-methoxybenzamide;FQWDVNSBYDXPIO-CQSZACIVSA-N;Benzamide, N-[2,3-dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-2-methoxy-;GSK6853 >=98% (HPLC) | | CAS: | 1910124-24-1 | | MF: | C22H27N5O3 | | MW: | 409.48 | | EINECS: | | | Product Categories: | API | | Mol File: | 1910124-24-1.mol |  |
| | GSK6853 Chemical Properties |
| Boiling point | 545.9±50.0 °C(Predicted) | | density | 1.247±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | Soluble in DMSO (25 mg/ml); ethanol (25 mg/ml) | | pka | 13.03±0.20(Predicted) | | form | solid | | color | White | | Optical Rotation | [α]/D -45 to -55°, c =0.3 in methanol | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. | | InChIKey | FQWDVNSBYDXPIO-CQSZACIVSA-N | | SMILES | O=C1N(C)C2=CC(N3CCNC[C@H]3C)=C(NC(C4=C(OC)C=CC=C4)=O)C=C2N1C |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | GSK6853 Usage And Synthesis |
| Uses | N-[2,3-Dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-2-methoxybenzamide can be used in biological study of preparation of bromodomain and PHD finger-containing protein inhibitors. | | Description | GSK6853 (1910124-24-1) is a very potent (pIC50 = 8.6 vs full length protein, 7.7 in cellular assays) inhibitor of Bromodomain and PHD Finger-containing 1 (BRPF1). It displayed >1600-fold selectivity over other bromodomains. | | Uses | N-[2,3-Dihydro-1,3-dimethyl-6-[(2R)-2-methyl-1-piperazinyl]-2-oxo-1H-benzimidazol-5-yl]-2-methoxybenzamide can be used in biological study of preparation of bromodomain and PHD finger-containing protein inhibitors. | | in vitro | in previous study, gsk6853 was tested in the bromoscan panel of bromodomain binding assays and the results showed that consistent with the previous findings, it showed excellent brpf1 potency (pkd 9.5) and greater than 1600-fold selectivity over all other bromodomains tested. in addition, screening gsk6853 against a panel of 48 unrelated assays revealed only off-target activities that were relatively weak compared to its high brpf1 potency [1]. | | in vivo | to assess the suitability of gsk6853 for in vivo studies, its dmpk characteristics were studied in male cd1 mice by i.v., po, and i.p. administration. the results indicated that the i.p. route of administration would be suitable for dosing this molecule in further pk/pd models. moreover, in order to be able to compare biochemical potency measurements to free blood concentrations, the fraction unbound in the cd1 mouse was also tested with a resulting value of 7.9% [1]. | | storage | Store at -20°C | | References | [1] PAUL BAMBOROUGH. GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain[J]. ACS Medicinal Chemistry Letters, 2016, 7 6: 552-557. DOI:10.1021/acsmedchemlett.6b00092 |
| | GSK6853 Preparation Products And Raw materials |
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