| Company Name: |
AdooQ Bioscience CHINA
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| Tel: |
025-58849295 18951903616; |
| Email: |
info@adooq.cn |
| Products Intro: |
Product Name:SRI-011381 hydrochloride
Purity:0.98 Package:1mg;5mg;10mg;25mg;50mg;100mg
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| | SRI-011381 (hydrochloride) Basic information |
| Product Name: | SRI-011381 (hydrochloride) | | Synonyms: | SRI-011381 (hydrochloride);SRI 011381 hydrochloride,multiple,Transforming growth factor beta,sclerosis,TGF-beta/Smad,α-SMA,NALP3,SRI 011381,collagen-1,SRI-011381,inhibit,TGF-β,neuroprotective,SRI011381,Inhibitor,SRI011381 hydrochloride;SRI-011381 hydrochloride, 10 mM in DMSO | | CAS: | 2070014-88-7 | | MF: | C20H32ClN3O | | MW: | 365.95 | | EINECS: | | | Product Categories: | | | Mol File: | 2070014-88-7.mol |  |
| | SRI-011381 (hydrochloride) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO : 33.33 mg/mL (91.08 mM) | | form | Solid | | color | White to off-white |
| | SRI-011381 (hydrochloride) Usage And Synthesis |
| Uses | SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects[1][2]. | | in vivo | SRI-011381 (30 mg/kg; i.p.; every 2 d; for 22 days) hydrochloride partially rescues the deficits in optic nerve and retina of YAPGFAP-CKO EAE mice[2]. | Animal Model: | YAPGFAP-CKO mice bearing experimental autoimmune encephalomyelitis (EAE)[2] | | Dosage: | 30 mg/kg | | Administration: | Intraperitoneally injection; every 2 d; for 22 days | | Result: | Significantly inhibited inflammatory infiltration and relieved the loss of neurons in YAPGFAP-CKO EAE mice. |
| | References | [1] Jingyin Han, et al. The Improvement Effect of Sodium Ferulate on the Formation of Pulmonary Fibrosis in Silicosis Mice Through the Neutrophil Alkaline Phosphatase 3 (NALP3)/Transforming Growth Factor-β1 (TGF-β1)/α-Smooth Muscle Actin (α-SMA) Pathway. Med Sci Monit. 2021 Jun 15;27:e927978. DOI:10.12659/MSM.927978
[2] Qian Wu, et al. Astrocytic YAP protects the optic nerve and retina in an experimental autoimmune encephalomyelitis model through TGF-β signaling. Theranostics. 2021 Jul 25;11(17):8480-8499. DOI:10.7150/thno.60031 |
| | SRI-011381 (hydrochloride) Preparation Products And Raw materials |
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