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| | 2-Methoxypyridine-3-boronic acid Basic information |
| | 2-Methoxypyridine-3-boronic acid Chemical Properties |
| Melting point | 140-144 °C | | Boiling point | 326.4±52.0 °C(Predicted) | | density | 1.24±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | soluble in Methanol | | form | Crystalline Powder | | pka | 6.90±0.58(Predicted) | | color | White | | InChI | InChI=1S/C6H8BNO3/c1-11-6-5(7(9)10)3-2-4-8-6/h2-4,9-10H,1H3 | | InChIKey | NVOLYUXUHWBCRJ-UHFFFAOYSA-N | | SMILES | B(C1=CC=CN=C1OC)(O)O | | CAS DataBase Reference | 163105-90-6(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29339900 | | Storage Class | 11 - Combustible Solids |
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ALFA
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| | 2-Methoxypyridine-3-boronic acid Usage And Synthesis |
| Chemical Properties | White to light brown powder | | Uses | 2-Methoxypyridine-3-boronic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research. | | General Description | May contain varying amounts of anhydride. | | Synthesis | The general procedure for the synthesis of 2-methoxypyridine-3-boronic acid from 2-methoxypyridine was as follows: 2-methoxypyridine (23.2 g) and diisopropylamine (1.35 mL) were dissolved in tetrahydrofuran (THF, 223 mL) at -20 °C, and lithium (trimethylsilylmethyl) was slowly added (218 mL, 13.8 wt% hexane solution). After 7 hours of reaction, the lithiation was 84% complete. Maintaining a temperature of -20 °C, triisopropyl borate (40.8 g) was added dropwise over 40 min. Subsequently, the reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, 5% aqueous sodium hydroxide solution (225 mL) was added for hydrolysis. After separation of the aqueous layer, the pH was adjusted with 10% aqueous hydrochloric acid solution to 5. The resulting white precipitate was collected by filtration. After drying, 22.23 g of 2-methoxypyridine-3-boronic acid was obtained in 68% yield. | | References | [1] Patent: WO2004/92125, 2004, A2. Location in patent: Page 8
[2] Journal of Organic Chemistry, 2005, vol. 70, # 1, p. 388 - 390
[3] Synthesis, 2003, # 7, p. 1035 - 1038 |
| | 2-Methoxypyridine-3-boronic acid Preparation Products And Raw materials |
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