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| | Propanedioic acid,2-[(2-nitrophenyl)methylene]-, 1,3-dimethyl ester Basic information |
| | Propanedioic acid,2-[(2-nitrophenyl)methylene]-, 1,3-dimethyl ester Chemical Properties |
| solubility | Chloroform: Soluble
Methanol: Soluble | | form | Solid | | color | White to off-white |
| | Propanedioic acid,2-[(2-nitrophenyl)methylene]-, 1,3-dimethyl ester Usage And Synthesis |
| Uses | NCI126224 is a TLR4 signaling inhibitor. NCI126224 suppress LPS (HY-D1056)-induced production of NF-κB, TNF-α, IL-1β, and NO in the nanomolar-low micromolar range. NCI126224 can be used for the research of inflammatory diseases[1]. | | References | [1] Zhang S, et, al. Selection, synthesis, and anti-inflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitors. Bioorg Med Chem. 2012 Oct 15;20(20):6073-9. DOI:10.1016/j.bmc.2012.08.022 |
| | Propanedioic acid,2-[(2-nitrophenyl)methylene]-, 1,3-dimethyl ester Preparation Products And Raw materials |
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