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| | 2-CYANO-3-HYDROXYPYRIDINE Basic information |
| | 2-CYANO-3-HYDROXYPYRIDINE Chemical Properties |
| Melting point | 211-212 °C (decomp) | | Boiling point | 429.2±30.0 °C(Predicted) | | density | 1.33±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO (Sparingly), Methanol (Slightly) | | form | Solid | | pka | 2.58±0.10(Predicted) | | color | Yellow to Dark Yellow | | InChI | InChI=1S/C6H4N2O/c7-4-5-6(9)2-1-3-8-5/h1-3,9H | | InChIKey | XTVFTOVNAKNVQK-UHFFFAOYSA-N | | SMILES | C1(C#N)=NC=CC=C1O | | CAS DataBase Reference | 932-35-4(CAS DataBase Reference) |
| | 2-CYANO-3-HYDROXYPYRIDINE Usage And Synthesis |
| Uses | 2-Cyano-3-hydroxypyridine can be used as eIF4A inhibitors. | | Synthesis | Example 3: 5.0 g of 1N hydrochloric acid and 1.0 g (6.31 mmol) of α-amino-2-furan acetonitrile hydrochloride were added to a three-neck flask at room temperature. The reaction mixture was cooled to 0 °C and 360 μL of bromine (6.94 mmol) was slowly added dropwise, followed by stirring at 0 °C for 1 hour. The reaction mixture was gradually warmed to room temperature and stirring was continued for 2 hours. After that, 32 μL of bromine was added to the reaction system and stirring was continued for 2 hours. Again, 32 μL of bromine was added and stirred for 1 hour. Upon completion of the reaction, 199 mg of sodium thiosulfate was added to the mixture to quench the reaction, followed by adjusting the pH with 40% NaOH aqueous solution to 3.0. The reaction mixture was filtered to afford a product containing 0.47 g of 2-cyano-3-hydroxypyridine. The yield of 2-cyano-3-hydroxypyridine was 62% based on the amount of α-amino-2-furylacetonitrile hydrochloride. | | References | [1] Patent: TW2016/510, 2016, A. Location in patent: Page/Page column 14
[2] Patent: WO2017/127794, 2017, A1
[3] Patent: WO2017/127791, 2017, A1
[4] Patent: TW2018/27404, 2018, A |
| | 2-CYANO-3-HYDROXYPYRIDINE Preparation Products And Raw materials |
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