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| | 3-(2-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Basic information |
| | 3-(2-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Chemical Properties |
| Boiling point | 124-125℃ (1.5 Torr) | | density | 1.164 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.516(lit.) | | Fp | >230 °F | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | form | Liquid | | pka | 10.03±0.46(Predicted) | | color | Colorless to Light orange to Yellow |
| WGK Germany | 3 | | HS Code | 2918.30.9000 |
| | 3-(2-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Usage And Synthesis |
| Uses | Ethyl (2-fluorobenzoyl)acetate may be used in chemical synthesis. | | Synthesis | GENERAL METHOD: An appropriate amount of diketone (9a or 9b) (0.3 mol) was mixed with ethanol (500 mL), heated to 80 °C and refluxed for 5 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was removed by distillation under reduced pressure to give the target product ester (10a or 10b) in the form of a red oil.
7.10.1 Preparation of ethyl 3-(2-fluorophenyl)-3-oxopropanoate (10a): the product obtained was a red oily material in 85% yield; mass spectrum (ESI) m/z: 233.1 [M + Na]? , 443.1 [2M + Na]? | | References | [1] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 11, p. 2843 - 2855
[2] Archiv der Pharmazie, 2013, vol. 346, # 7, p. 521 - 533
[3] Patent: EP2799437, 2014, A1. Location in patent: Paragraph 0057
[4] Patent: US2014/364431, 2014, A1. Location in patent: Paragraph 0188
[5] Patent: WO2017/37672, 2017, A1. Location in patent: Page/Page column 48 |
| | 3-(2-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER Preparation Products And Raw materials |
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