3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, (3R,4R)-

3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, (3R,4R)- Suppliers list
Company Name: BOC Sciences
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Products Intro: Product Name:ICEC-0942
CAS:1805833-75-3
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Products Intro: Product Name:ICEC 0942
CAS:1805833-75-3
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CAS:1805833-75-3
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CAS:1805833-75-3
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Products Intro: Product Name:(3R,4R)-4-(((7-(benzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-yl)amino)methyl)piperidin-3-ol
CAS:1805833-75-3
Purity:95% Package:1G;2G;5G
3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, (3R,4R)- Basic information
Product Name:3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, (3R,4R)-
Synonyms:3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, (3R,4R)-;PPDA-001;ICEC0942 (CT7001) Free base;ICEC-0942;CT7001);ICEC 0942 (ICEC0942;Samuraciclib;(3R,4R)-4-(((7-(benzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-yl)amino)methyl)piperidin-3-ol
CAS:1805833-75-3
MF:C22H30N6O
MW:394.51
EINECS:
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Mol File:1805833-75-3.mol
3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, (3R,4R)- Structure
3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, (3R,4R)- Chemical Properties
density 1.30±0.1 g/cm3(Predicted)
pka14.69±0.40(Predicted)
Safety Information
MSDS Information
3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, (3R,4R)- Usage And Synthesis
UsesSamuraciclib can be used to treat tuberous sclerosis complex using cyclin dependent kinase 7 (CDK7) inhibitors.
in vivo

Samuraciclib (ICEC0942; 100 mg/kg; oral gavage; daily; for 14 days; female nu/nu-BALB/c athymic nude mice) treatment inhibits tumor growth by 60% at day 14, and is accompanied by highly significant reductions in PolII Ser2 and Ser5 phosphorylation in PBMCs and in tumors[1].
The combination of Samuraciclib (ICEC0942) and ICI 47699 treatment shows complete growth arrest of estrogen receptor (ER)-positive tumor xenografts[1].

Animal Model:Female nu/nu-BALB/c athymic nude mice (7-week old) with MCF7 cells[1].
Dosage:100 mg/kg
Administration:Oral gavage; daily; for 14 days
Result:At day 14, tumor growth was inhibited by 60%.
IC 50CDK7/CycH/MAT1: 41 nM (IC50); CDK2/cycE1: 578 nM (IC50); CDK1: 1.8 μM (IC50); CDK4: 49 μM (IC50); CDK5: 9.4 μM (IC50); CDK6: 34 μM (IC50); CDK9: 1.2 μM (IC50)
3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, (3R,4R)- Preparation Products And Raw materials
Tag:3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, (3R,4R)-(1805833-75-3) Related Product Information

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