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| | 5-FLUORO-4-FORMYL-2-METHOXYPYRIDINE Basic information |
| Product Name: | 5-FLUORO-4-FORMYL-2-METHOXYPYRIDINE | | Synonyms: | 5-FLUORO-4-FORMYL-2-METHOXYPYRIDINE;5-Fluoro-2-methoxyisonicotinaldehyde;5-Fluoro-2-methoxypyridine-4-carboxaldehyde;4-PYRIDINECARBOXALDEHYDE, 5-FLUORO-2-METHOXY-;5-fluoro-2-methoxypyridine-4-carbaldehyde;5-FLUORO-4-FORMYL-2-METHOXYPYRIDINE ISO 9001：2015 REACH;5-fluoro-2-methoxy-pyridine-4-carbaldehyde - [F87726] | | CAS: | 884495-12-9 | | MF: | C7H6FNO2 | | MW: | 155.13 | | EINECS: | | | Product Categories: | Boronic Acid;Heterocyclic Compounds | | Mol File: | 884495-12-9.mol |  |
| | 5-FLUORO-4-FORMYL-2-METHOXYPYRIDINE Chemical Properties |
| Boiling point | 234℃ | | density | 1.266 | | Fp | 96℃ | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | Appearance | White to off-white Solid |
| | 5-FLUORO-4-FORMYL-2-METHOXYPYRIDINE Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 2-methoxy-5-fluoropyridine-4-carboxaldehyde from (5-fluoro-2-methoxypyridin-4-yl)methanol was as follows: (5-fluoro-2-methoxypyridin-4-yl)methanol (1.40 g, 8.91 mmol) was dissolved in dichloromethane (DCM, 50 mL) with stirring. A dichloromethane (DCM, 70 mL) solution of Dess-Martin periodontane (4.535 g, 10.69 mmol) was slowly added and the reaction mixture continued to be stirred for 1.5 hours at room temperature. After completion of the reaction, the organic layer was washed sequentially with 1 M aqueous sodium hydroxide solution (2 x 75 mL), water (75 mL) and brine, dried over anhydrous magnesium sulfate (MgSO), filtered and concentrated to afford 2-methoxy-5-fluoropyridine-4-carbaldehyde as a yellow oil (0.481 g, 35% yield).1H NMR (399.902 MHz, CDCl) δ 3.94 (s, 3H), 7.08-7.11 (m, 1H), 8.20-8.22 (m, 1H), 10.32 (s, 1H). | | References | [1] Patent: US2008/4302, 2008, A1. Location in patent: Page/Page column 74 |
| | 5-FLUORO-4-FORMYL-2-METHOXYPYRIDINE Preparation Products And Raw materials |
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