- Pinostrobin
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- $1.00 / 1KG
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2024-08-11
- CAS:480-37-5
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 20000KG
- Pinostrobin
-
- $1.00 / 1KG
-
2019-12-31
- CAS:480-37-5
- Min. Order: 1KG
- Purity: 95-99%
- Supply Ability: 1ton
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| | Pinostrobin Basic information |
| Product Name: | Pinostrobin | | Synonyms: | 2,3-Dihydro-5-hydroxy-7-methoxy-2-phenyl-4H-1-benzopyran-4-one;2-Phenyl-5-hydroxy-7-methoxy-2,3-dihydro-4H-1-benzopyran-4-one;Pinostobin;Pistrobin;Pinostrobin,(S)-2,3-Dihydro-5-hydroxy-7-methoxy-2-phenyl-4H-1-benzopyran-4-one;PINOCEMBRIN-7-METHYLETHER(RG)(PLEASE CALL);5-Hydroxy-7-methoxy-2-phenyl-chroman-4-one;5-Hydroxy-7-methoxyflavanone | | CAS: | 480-37-5 | | MF: | C16H14O4 | | MW: | 270.28 | | EINECS: | 207-548-1 | | Product Categories: | Flavanones | | Mol File: | 480-37-5.mol |  |
| | Pinostrobin Chemical Properties |
| Melting point | 100°C | | Boiling point | 494.9±45.0 °C(Predicted) | | density | 1.284±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMF: 20 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 12 mg/ml | | form | A crystalline solid | | pka | 7.40±0.40(Predicted) | | color | White to yellow | | InChI | InChI=1S/C16H14O4/c1-19-11-7-12(17)16-13(18)9-14(20-15(16)8-11)10-5-3-2-4-6-10/h2-8,14,17H,9H2,1H3/t14-/m0/s1 | | InChIKey | ORJDDOBAOGKRJV-AWEZNQCLSA-N | | SMILES | [C@H]1(C2=CC=CC=C2)OC2=CC(OC)=CC(O)=C2C(=O)C1 | | LogP | 3.591 (est) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| | Pinostrobin Usage And Synthesis |
| Description | Pinostrobin is a flavonoid with diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties. It induces quinone reductase (QR) in murine hepatoma cells with a QR doubling concentration of 500 nM. Pinostrobin inhibits TNF-α and IL-1β production in RAW 264.7 macrophages (IC50s = 17.28 and 23.5 μM, respectively) and in LPS-stimulated rats (48.6 and 55% reduction, respectively). Pinostrobin also shows selective cytotoxicity for CCRF-CEM leukemia cells (IC50 = 10.2 μM) in a panel of eight cancer cell lines (IC50s = >30 μM). | | Uses | Pinostrombin is a useful research chemical that can be used for chemical fingerprinting, isolating, and characterizing of polyphenol compounds. It can also be used as a potential compound for TMPRSS2 inhibition for Covid-19 therapy. | | Definition | ChEBI: A monohydroxyflavanone that is (2S)-flavanone substituted by a hydroxy group at position 5 and a methoxy group at position 7 respectively. |
| | Pinostrobin Preparation Products And Raw materials |
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