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sales@invivochem.cn |
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AODDRWVLAXJCBA-UHFFFAOYSA-N manufacturers
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| | AODDRWVLAXJCBA-UHFFFAOYSA-N Basic information |
| Product Name: | AODDRWVLAXJCBA-UHFFFAOYSA-N | | Synonyms: | AODDRWVLAXJCBA-UHFFFAOYSA-N;PSI-7409 tetrasodium;2'-Deoxy-2'-fluoro-2'-C-methyluridine 5'-triphosphate sodium salt;PSI 7409 tetrasodium,PSI7409 tetrasodium;Sodium ((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-fluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methyl triphosphate | | CAS: | 1621884-22-7 | | MF: | C10H17FN2NaO14P3 | | MW: | 524.16 | | EINECS: | | | Product Categories: | | | Mol File: | 1621884-22-7.mol |  |
| | AODDRWVLAXJCBA-UHFFFAOYSA-N Chemical Properties |
| storage temp. | Store at -20°C | | form | Solid | | color | White to off-white | | Water Solubility | Water : ≥ 125 mg/mL (211.11 mM) |
| | AODDRWVLAXJCBA-UHFFFAOYSA-N Usage And Synthesis |
| Uses | PSI-7409 tetrasodium is an active 5'-triphosphate metabolite of sofosbuvir (PSI-7977), inhibiting HCV NS5B polymerases, with IC50s of 1.6, 2.8, 0.7 and 2.6 μM for GT 1b_Con1, GT 2a_JFH1, GT 3a, and GT 4a NS5B polymerases, respectively. | | References | [1] Lam AM, et al. PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. Antimicrob Agents Chemother. 2010 Aug;54(8):3187-96. DOI:10.1128/AAC.00399-10
[2] Murakami E, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. J Biol Chem. 2010 Nov 5;285(45):34337-47. DOI:10.1074/jbc.M110.161802 |
| | AODDRWVLAXJCBA-UHFFFAOYSA-N Preparation Products And Raw materials |
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