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| | BWMISRWJRUSYEX-YOVIYTQZSA-N Basic information |
| Product Name: | BWMISRWJRUSYEX-YOVIYTQZSA-N | | Synonyms: | BWMISRWJRUSYEX-YOVIYTQZSA-N;Terbinafine-d3HCl (N-methyl-d3);N-[-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-(methyl-d3)-1-naphthalenemethanamine,monohydrochloride;Famotidine EP Impurity F-d4;Terbinafine-D3 Hydrochloride (Standard) | | CAS: | 1310012-15-7 | | MF: | C21H26ClN | | MW: | 327.9 | | EINECS: | | | Product Categories: | | | Mol File: | 1310012-15-7.mol |  |
| | BWMISRWJRUSYEX-YOVIYTQZSA-N Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 14 mg/ml,DMSO: 10 mg/ml,Ethanol: 30 mg/ml | | form | A solid | | color | White to off-white | | Stability: | Hygroscopic |
| | BWMISRWJRUSYEX-YOVIYTQZSA-N Usage And Synthesis |
| Description | Terbinafine-d3 is intended for use as an internal standard for the quantification of terbinafine by GC- or LC-MS. Terbinafine is a broad-spectrum antifungal agent that has activity against T. rubrum, T. mentagrophytes, T. verrucosum, E. floccosum, M. canis, A. fumigatus, and S. schenckii (MIC50s = 0.003-0.8 μg/ml). It selectively inhibits C. albicans squalene epoxidase over rat liver epoxidase (IC50s = 0.03 and 77 μM, respectively). Terbinafine (90-120 μM) induces cell cycle arrest at the G0/G1 phase in COLO 205 tumor cells and human umbilical vein endothelial cells (HUVECs). Formulations containing terbinafine have been used in the treatment of nail and skin fungal infections. | | Uses | Terbinafine-d3 HCl (N-methyl-d3) (CAS# 1310012-15-7) is a useful isotopically labeled research compound. | | References | [1] G PETRANYI H M J G Meingassner. Antifungal activity of the allylamine derivative terbinafine in vitro.[J]. Antimicrobial Agents and Chemotherapy, 1987, 31 9: 1365-1368. DOI: 10.1128/aac.31.9.1365
[2] N S RYDER M C D. Inhibition of squalene epoxidase by allylamine antimycotic compounds. A comparative study of the fungal and mammalian enzymes.[J]. Biochemical Journal, 1985, 230 3: 765-770. DOI: 10.1042/bj2300765
[3] WEN-SEN LEE. In vitro and in vivo studies of the anticancer action of terbinafine in human cancer cell lines: G0/G1 p53-associated cell cycle arrest[J]. International Journal of Cancer, 2003, 106 1: 125-137. DOI: 10.1002/ijc.11194
[4] PEI-YIN HO. Inhibition of human vascular endothelial cells proliferation by terbinafine[J]. International Journal of Cancer, 2004, 111 1: 51-59. DOI: 10.1002/ijc.20039 |
| | BWMISRWJRUSYEX-YOVIYTQZSA-N Preparation Products And Raw materials |
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