- 1-(2-Pyridyl)piperazine
-
-
2020-01-08
- CAS:34803-66-2
- Min. Order: 1KG
- Purity: 98%;99%
- Supply Ability: 1kg； 5kg；10kg；25kg
|
| | 1-(2-Pyridyl)piperazine Basic information |
| | 1-(2-Pyridyl)piperazine Chemical Properties |
| Melting point | 92-94 | | Boiling point | 120-122 °C/2 mmHg (lit.) | | density | 1.072 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.595(lit.) | | Fp | >230 °F | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | Soluble in Chloroform, Methanol. | | form | Liquid | | pka | 8.63±0.10(Predicted) | | color | Clear colorless to yellow | | Water Solubility | >500 g/L (20 ºC) | | Sensitive | Air Sensitive | | BRN | 140423 | | InChI | 1S/C9H13N3/c1-2-4-11-9(3-1)12-7-5-10-6-8-12/h1-4,10H,5-8H2 | | InChIKey | GZRKXKUVVPSREJ-UHFFFAOYSA-N | | SMILES | C1CN(CCN1)c2ccccn2 | | CAS DataBase Reference | 34803-66-2(CAS DataBase Reference) | | NIST Chemistry Reference | 1-(2-Pyridyl)piperazine(34803-66-2) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | RIDADR | 2735 | | WGK Germany | 3 | | F | 10-34 | | Hazard Note | Irritant | | HazardClass | 8 | | PackingGroup | II | | HS Code | 29339900 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 1-(2-Pyridyl)piperazine Usage And Synthesis |
| Chemical Properties | clear colourless to yellow liquid | | Uses | 1-(2-Pyridyl)piperazine is a compound that belongs to a class of selective α2-adrenoceptor antagonists. 1-(2-Pyridyl)piperazine shows sympatholytic activity. 1-(2-Pyridyl)piperazine is also a metaboli
te of Azaperone (A802200). | | Uses | 1-(2-Pyridyl)piperazine was used to determine the aliphatic and aromatic isocyanates in air. | | General Description | 1-(2-Pyridyl)piperazine is a piperazine derivative. | | Synthesis | Step 1: 0.1 g (0.63 mmol) of 2-bromopyridine and 0.065 g (0.75 mmol) of piperazine were placed in a dry 5 mL microwave reactor protected by nitrogen and reacted at 150 °C for 20 min. After completion of the reaction, it was cooled to room temperature. Step 2: The reaction mixture was filtered using diatomaceous earth and the filter cake was washed with ethyl acetate. Step 3: The solvent was removed by distillation under reduced pressure to obtain the crude product. Step 4: Purification of the crude product by silica gel column chromatography with eluent ratio of dichloromethane:methanol=4:1 to obtain 1-(pyridin-2-yl)piperazine in 54% yield. | | References | [1] Patent: WO2008/153325, 2008, A1. Location in patent: Page/Page column 43
[2] Patent: WO2006/47415, 2006, A2. Location in patent: Page/Page column 37-38
[3] Journal of the American Chemical Society, 1949, vol. 71, p. 2731,2732
[4] Journal of Organic Chemistry, 1953, vol. 18, p. 1484,1487
[5] Patent: WO2008/62276, 2008, A2. Location in patent: Page/Page column 50 |
| | 1-(2-Pyridyl)piperazine Preparation Products And Raw materials |
|