1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol:hydrochloride

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1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol:hydrochloride manufacturers
1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol:hydrochloride Basic information
Product Name:1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol:hydrochloride
Synonyms:1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol:hydrochloride;BM-15275 hydrochloride;KT-611 hydrochloride;BM-15275,BM15275,canine,prostatic,Naftopidil,prostate,hyperplasia,inhibit,Inhibitor,Naftopidil hydrochloride,KT-611,Adrenergic Receptor,KT611,KT 611,pressure,BM 15275,Beta Receptor;Emorfazone Impurity 3;Naftopidil hydrochloride, 10 mM in DMSO
CAS:1164469-60-6
MF:C24H29ClN2O3
MW:428.95166
EINECS:
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Mol File:1164469-60-6.mol
1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol:hydrochloride Structure
1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol:hydrochloride Chemical Properties
storage temp. Store at -20°C
solubility DMF: 10 mg/mL; DMF:PBS (pH 7.2) (1:4): 0.2 mg/mL; DMSO: 3 mg/mL
form A crystalline solid
Safety Information
MSDS Information
1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol:hydrochloride Usage And Synthesis
UsesNaftopidil Hydrochloride is an α-1-adrenergic receptor antagonist. Naftopidil is used as an antihypertensive.
in vivo

Naftopidil hydrochloride (10 mg/kg; p.o; daily; for 28 days) decreases microvessel density (MVD) in E9+PrSC tumors mice model[2].

Animal Model:Male athymic mice(7-8 weeks), with E9+PrSC xenograft[2]
Dosage:10 mg/kg
Administration:Oral administration, daily, for 28 days
Result:Decreased tumor weights.
IC 50Alpha-1A adrenergic receptor: 3.7 nM (Ki); Alpha-1B adrenergic receptor: 20 nM (Ki); Alpha-1D adrenergic receptor: 1.2 nM (Ki)
storageStore at RT
1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol:hydrochloride Preparation Products And Raw materials
Tag:1-[4-(2-methoxyphenyl)piperazin-1-yl]-3-naphthalen-1-yloxypropan-2-ol:hydrochloride(1164469-60-6) Related Product Information
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