1-(2,4-dimethylphenyl)-4-(3-methylpiperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine

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1-(2,4-dimethylphenyl)-4-(3-methylpiperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine Basic information
Product Name:1-(2,4-dimethylphenyl)-4-(3-methylpiperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine
Synonyms:1-(2,4-dimethylphenyl)-4-(3-methylpiperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine;VU0080241;1H-Pyrazolo[3,4-d]pyrimidine, 1-(2,4-dimethylphenyl)-4-(3-methyl-1-piperidinyl)-
CAS:393845-24-4
MF:C19H23N5
MW:321.42
EINECS:
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Mol File:393845-24-4.mol
1-(2,4-dimethylphenyl)-4-(3-methylpiperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine Structure
1-(2,4-dimethylphenyl)-4-(3-methylpiperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine Chemical Properties
Boiling point 447.5±45.0 °C(Predicted)
density 1.24±0.1 g/cm3(Predicted)
pka4.83±0.30(Predicted)
form Solid
color Yellow to orange
Safety Information
MSDS Information
1-(2,4-dimethylphenyl)-4-(3-methylpiperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine Usage And Synthesis
DescriptionVU0080241 is a positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4).
UsesVU0080241 is a positive allosteric modulator (PAM) of the metabotropic glutamate receptor subtype 4 (mGluR4), with an EC50 of 4.6 μM[1].
IC 50mGlu4: 4.6 μM (EC50)
References[1] Colleen M Niswender, et al. Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators. Bioorg Med Chem Lett. 2008 Oct 15; 18(20) DOI:10.1016/j.bmcl.2008.08.087
1-(2,4-dimethylphenyl)-4-(3-methylpiperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine Preparation Products And Raw materials
Tag:1-(2,4-dimethylphenyl)-4-(3-methylpiperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine(393845-24-4) Related Product Information
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