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| | 4-(Bromoacetyl)pyridine hydrobromide Basic information |
| | 4-(Bromoacetyl)pyridine hydrobromide Chemical Properties |
| Melting point | 194 °C | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | form | powder | | color | Off-white | | Water Solubility | Soluble in water. | | CAS DataBase Reference | 5349-17-7(CAS DataBase Reference) |
| | 4-(Bromoacetyl)pyridine hydrobromide Usage And Synthesis |
| Uses | Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase 4-(Bromoacetyl)pyridine hydrobromide was used to prepare 2-Phenyl-4-(4-pyridyl)imidazole. | | Synthesis | General procedure for the synthesis of 4-(bromoacetyl)pyridine hydrobromide from 4-acetylpyridine: 558 g of batch master batch was added to a reaction flask, followed by the addition of 42 g of ethyl acetate, and 121.1 g of 4-acetylpyridine was added slowly with stirring, keeping the reaction temperature at 20~30 °C and stirring well. N-bromosuccinimide (NBS) 186.9 g was added in batches, followed by slow warming to 65~75 °C. The progress of the reaction was monitored by thin layer chromatography (TLC) until the feedstock was fully reacted. After completion of the reaction, the reaction mixture was cooled to 0~10°C to allow complete crystallization of the product. The crystals were collected by filtration, washed and pulped with 650 g of deionized water, filtered again, and dried to give 275.6 g of 4-(bromoacetyl)pyridine hydrobromide as a white solid in 98.1% molar yield. | | References | [1] Patent: WO2005/73225, 2005, A1. Location in patent: Page/Page column 49-50
[2] Patent: CN106632001, 2017, A. Location in patent: Paragraph 0026; 0027; 0028; 0029
[3] Journal of Medicinal Chemistry, 2010, vol. 53, # 2, p. 787 - 797
[4] Patent: WO2009/158393, 2009, A1. Location in patent: Page/Page column 51
[5] Patent: US2007/142415, 2007, A1. Location in patent: Page/Page column 17 |
| | 4-(Bromoacetyl)pyridine hydrobromide Preparation Products And Raw materials |
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