| Company Name: |
BOC Sciences |
| Tel: |
16314854226; +8616314854226 |
| Email: |
inquiry@bocsci.com |
OP-0595 manufacturers
- Nacubactam
-
- $54.00
-
2026-08-13
- CAS:1452458-86-4
- Purity: 99.30%
- Supply Ability: 10g
- Nacubactam
-
- $54.00
-
2026-08-13
- CAS:1452458-86-4
- Purity: 99.30%
- Supply Ability: 10g
|
| | OP-0595 Basic information |
| Product Name: | OP-0595 | | Synonyms: | OP-0595;OP0595 free acid;Sulfuric acid, mono[(1R,2S,5R)-2-[[(2-aminoethoxy)amino]carbonyl]-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester;OP 0595,Nacubactam,OP0595,inhibit,OP-0595,Bacterial,Inhibitor;(1R,2S,5R)-2-((2-Aminoethoxy)carbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate;Nacubactam, 10 mM in DMSO;(2s,5r)-2-(2-aminoethoxycarbamoyl)-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate | | CAS: | 1452458-86-4 | | MF: | C9H16N4O7S | | MW: | 324.31 | | EINECS: | | | Product Categories: | | | Mol File: | 1452458-86-4.mol |  |
| | OP-0595 Chemical Properties |
| density | 1.71±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C, protect from light, stored under nitrogen | | solubility | Soluble in DMSO | | form | Solid | | pka | -4.59±0.18(Predicted) | | color | White to light brown |
| | OP-0595 Usage And Synthesis |
| Uses | Nacubactam (OP0595 free acid) is a potent non-β-lactam-β-lactamase inhibitor with activity against class A and class C β-lactamases. Nacubactam (OP0595 free acid) acts as a penicillin binding protein (PBP) 2-active antibacterial, and gives β-lactamase-independent potentiation of β-lactams targeting other PBPs[1][2]. | | References | [1] Monogue ML, et al. In Vivo Efficacy of Meropenem with a Novel Non-β-Lactam-β-Lactamase Inhibitor, Nacubactam, against Gram-Negative Organisms Exhibiting Various Resistance Mechanisms in a Murine Complicated Urinary Tract Infection Model. Antimicrob Agents Chemother. 2018 Aug 27;62(9). DOI:10.1128/AAC.02596-17
[2] Livermore DM, et al. Activity of OP0595/β-lactam combinations against Gram-negative bacteria with extended-spectrum, AmpC and carbapenem-hydrolysing β-lactamases. J Antimicrob Chemother. 2015 Nov;70(11):3032-41. DOI:10.1093/jac/dkv239 |
| | OP-0595 Preparation Products And Raw materials |
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