5-HYDROXY-2'-DEOXYURIDINE
| 中文名称 | 5-HYDROXY-2'-DEOXYURIDINE |
|---|---|
| 中文同义词 | 5-羟基-2'-脱氧尿苷;化合物 T19152;2'-脱氧-5-羟基尿苷;化合物 5-OHDU;化合物 5-OHDU,10 MM DMSO 溶液;化合物:5-Hydroxy-2'-deoxyuridine CAS:5168-36-5;化合物：5-Hydroxy-2'-deoxyuridine CAS:5168-36-5 |
| 英文名称 | 5-HYDROXY-2'-DEOXYURIDINE |
| 英文同义词 | 2'-DEOXY-5-HYDROXY-D-URIDINE;5-HYDROXY-2'-DEOXYURIDINE;Oh-5-du;Uridine, 2'-deoxy-5-hydroxy-;2'-Deoxy-5-hydroxyuridine;5-OHdU;5-OHdU, 10 mM in DMSO |
| CAS号 | 5168-36-5 |
| 分子式 | C9H12N2O6 |
| 分子量 | 244.2 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 5168-36-5.mol |
| 结构式 |  |
5-HYDROXY-2'-DEOXYURIDINE 性质
| 储存条件 | Hygroscopic, -20°C Freezer, Under inert atmosphere |
|---|---|
| 溶解度 | 加热、超声处理轻微溶于甲醇、轻微溶于水 |
| 形态 | 固体 |
| 颜色 | 白色至类白色 |
| 水溶解性 | Water: 10 mg/mL (40.95 mM) |
| 稳定性 | 吸湿性 |
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Human Endogenous Metabolite
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To study the specificity of nucleotide incorporation opposite 5-hydroxypyrimidines in template DNA, 18- and 45-member oligodeoxyribonucleotides, containing an internal 2'-deoxy-5-hydroxyuridine (5-OHdU) in two different sequence contexts, were used. Translesion synthesis past 2'-deoxy-5-hydroxyuridine (5-OHdU) in both oligonucleotides occurred, but pauses both opposite, and one nucleotide prior to, the modified base in the template is observed. The specificity of nucleotide incorporation opposite 2'-deoxy-5-hydroxyuridine (5-OHdU) in the template is sequence context dependent. In one sequence context, dA is the principal nucleotide incorporated opposite 2'-deoxy-5-hydroxyuridine (5-OHdU). However in a second sequence context, dC is the predominant base incorporated opposite 2'-deoxy-5-hydroxyuridine (5-OHdU). In that same sequence context, dC is also the predominant nucleotide incorporated opposite 2'-deoxy-5-hydroxyuridine (5-OHdU).