|
|
| | Naloxone hydrochloride dihydrate Basic information |
| | Naloxone hydrochloride dihydrate Chemical Properties |
| Melting point | 182 °C (dec.)(lit.) | | storage temp. | 2-8°C | | solubility | ethanol: 3.3 mg/mL stable for several months refrigerated if protected from light. | | form | powder | | color | white to off-white | | Optical Rotation | [α]25/D 178.6°, c = 2.5 in H2O(lit.) | | Merck | 13,6388 | | BRN | 6260807 | | InChIKey | TXMZWEASFRBVKY-VGCNNFRWNA-N | | SMILES | [C@@]123CCN(CC=C)[C@@H]4CC5=CC=C(O)C(O[C@H]1C(CC[C@]24O)=O)=C35.O.O.Cl |&1:0,7,16,20,r| | | CAS DataBase Reference | 51481-60-8(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 22-24/25-26-36/37/39-36 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | Naloxone hydrochloride dihydrate Usage And Synthesis |
| Chemical Properties | White or almost white, hygroscopic, crystalline powder. | | Uses | Naloxone Hydrochloride Dihydrate is a specific opioid antagonist. Narcotic antagonist. | | Uses | Antagonist (to narcotics). | | Brand name | Narcan (Bristol-Myers Squibb); Narcan (Endo). | | Biochem/physiol Actions | Competitive antagonist for μ, κ, δ, and σ opioid receptors; blocks the action of σ-agonists at opioid sites. Naloxone′s antagonistic effect last for about 45 min and thus, requires repeated dosage. It results in critical side effects such as pulmonary edema. | | Purification Methods | This opiate antagonist has been recrystallised from EtOH/Et2O or H2O. It is soluble in H2O (5%) and EtOH but insoluble in Et2O. The free base has m 184o (177-178o also reported) after recrystallisation from EtOAc, and [] D -194.5o (c 0.93, CHCl3). [Olofson et al. Tetrahedron Lett 1567 1977, Gold et al. Med Res Rev 2 211 1982.] |
| | Naloxone hydrochloride dihydrate Preparation Products And Raw materials |
|