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| | IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID Basic information |
| Product Name: | IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID | | Synonyms: | IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID;H-imidazo[1,2-a]pyridine-8-carboxylic acid;Imidazo[1,2-a]pyridine-8-...;8-imidazo[1,2-a]pyridinecarboxylic acid;IMidazo[1,2-a]pyridin-8-carboxylic acid;H-iMidazo[1,2-a]pyridine-8-carbo×ylic acid;Imidazo[1,2-a]pyridine-8-carboxylicaci;IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID ISO 9001：2015 REACH | | CAS: | 133427-08-4 | | MF: | C8H6N2O2 | | MW: | 162.15 | | EINECS: | | | Product Categories: | CHIRAL CHEMICALS | | Mol File: | 133427-08-4.mol | ![IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID Structure](CAS/GIF/133427-08-4.gif) |
| | IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID Chemical Properties |
| density | 1.41 | | storage temp. | Sealed in dry,Room Temperature | | form | solid | | pka | -0.61±0.41(Predicted) | | color | White |
| Hazard Codes | Xn | | Risk Statements | 22-43 | | Safety Statements | 36/37 | | HS Code | 2933399990 |
| | IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID Usage And Synthesis |
| Synthesis | General procedure for the synthesis of imidazo[1,2-a]pyridine-8-carboxylic acid from 2-aminonicotinic acid and 2-bromo-1,1-dimethoxyethane: To a suspension of 2-aminonicotinic acid (0.69 g, 5.00 mmol) in acetonitrile (20 mL) was added 2-bromo-1,1-dimethoxyethane (0.59 mL, 5.00 mmol). The resulting mixture was heated to 150 °C in a microwave reactor and kept for 2 hours. After completion of the reaction, the precipitate was collected by filtration and washed sequentially with acetonitrile and hexane to afford imidazo[1,2-a]pyridine-8-carboxylic acid (0.924 g) as a gray solid. | | References | [1] Patent: WO2009/23253, 2009, A2. Location in patent: Page/Page column 52
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 5, p. 1870 - 1873 |
| | IMIDAZO[1,2-A]PYRIDINE-8-CARBOXYLIC ACID Preparation Products And Raw materials |
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