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Alabiotech Inc. |
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| | MMP-9/MMP-13 INHIBITOR I Basic information |
| Product Name: | MMP-9/MMP-13 INHIBITOR I | | Synonyms: | MMP-9/MMP-13 INHIBITOR I;MMP-9/MMP-13 INHIBITOR II;N-HYDROXY-1-(4-METHOXYPHENYL)SULFONYL-4-(4-BIPHENYLCARBONYL)PIPERAZINE-2-CARBOXAMIDE;N-HYDROXY-1-(4-METHOXYPHENYL)SULFONYL-4-BENZYLOXYCARBONYLPIPERAZINE-2-CARBOXAMIDE;2-Piperazinecarboxamide, 4-([1,1'-biphenyl]-4-ylcarbonyl)-N-hydroxy-1-[(4-methoxyphenyl)sulfonyl]-;MMP-9/MMP-13 Inhibitor I - CAS 204140-01-2 - Calbiochem[444252] | | CAS: | 204140-01-2 | | MF: | C25H25N3O6S | | MW: | 495.55 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | MMP-9/MMP-13 INHIBITOR I Chemical Properties |
| density | 1.364±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO or methanol | | pka | 9.38±0.23(Predicted) | | form | Solid | | color | White to off-white | | Sensitive | Light Sensitive |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | MMP-9/MMP-13 INHIBITOR I Usage And Synthesis |
| Description | MMP-9/MMP-13 inhibitor I is a cell-permeable inhibitor of matrix metalloproteinases (MMPs) that most potently inhibits MMP-9 and MMP-13 (IC50s = 0.9 nM for both). It less effectively inhibits MMP-1, MMP-3, and MMP-7 (IC50s = 43, 23, and 920 nM, respectively). MMP-9/MMP-13 inhibitor I has been used to elucidate the roles of MMPs in biological systems, including tumor cell invasion and pathogenesis of P. falciparum. | | Uses | A piperazine-based, cell-permeable, and highly potent inhibitor of MMP-9 and MMP-13 | | IC 50 | MMP-9: 0.9 nM (IC50); MMP-13: 0.9 nM (IC50); MMP-1: 43 nM (IC50); MMP-3: 23 nM (IC50); MMP-7: 931 nM (IC50) | | References | [1] MENYAN CHENG. Design and Synthesis of Piperazine-Based Matrix Metalloproteinase Inhibitors[J]. Journal of Medicinal Chemistry, 2000, 43 3: 369-380. DOI: 10.1021/jm990366q
[2] MAURO PRATO. Phagocytosis of hemozoin enhances matrix metalloproteinase-9 activity and TNF-alpha production in human monocytes: role of matrix metalloproteinases in the pathogenesis of falciparum malaria.[J]. Journal of immunology, 2005, 175 10: 6436-6442. DOI: 10.4049/jimmunol.175.10.6436
[3] PETER STORZ. FOXO3a promotes tumor cell invasion through the induction of matrix metalloproteinases.[J]. Molecular and Cellular Biology, 2009, 29 18: 4906-4917. DOI: 10.1128/mcb.00077-09
[4] MUTHULEKHA SWAMYDAS. Mesenchymal stem cell-derived CCL-9 and CCL-5 promote mammary tumor cell invasion and the activation of matrix metalloproteinases.[J]. Cell Adhesion & Migration, 2013, 7 3: 315-324. DOI: 10.4161/cam.25138 |
| | MMP-9/MMP-13 INHIBITOR I Preparation Products And Raw materials |
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