| Company Name: |
BOC Sciences
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| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:H4 Receptor antagonist 1
CAS:848217-00-5
Purity:>=95% Remarks:Reach out to us for more information about custom solutions.
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| Company Name: |
Shanghai Sainty Biotechnology Co., Ltd.
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| Tel: |
021-58957915 17721108391 |
| Email: |
907522080@qq.com |
| Products Intro: |
Product Name:8-chloro-2-methyl-4-(4-methylpiperazin-1-yl)-[1]benzofuro[3,2-d]pyrimidine
CAS:848217-00-5
Purity:98% Package:1 g/1;5 g/1;10 g/1
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| | 8-chloro-2-methyl-4-(4-methylpiperazin-1-yl)-[1]benzofuro[3,2-d]pyrimidine Basic information |
| | 8-chloro-2-methyl-4-(4-methylpiperazin-1-yl)-[1]benzofuro[3,2-d]pyrimidine Chemical Properties |
| density | 1.328±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 10 mg/mL (31.57 mM) | | form | Solid | | pka | 6.73±0.42(Predicted) | | color | White to off-white |
| | 8-chloro-2-methyl-4-(4-methylpiperazin-1-yl)-[1]benzofuro[3,2-d]pyrimidine Usage And Synthesis |
| Uses | H4 Receptor antagonist 1 is a potent and selective histamine H4 receptor inverse agonist, with an IC50 of 19 nM. | | in vivo | H4 Receptor antagonist 1 indicates that metabolic stability in rat microsomes is very low with only 1% parent compound remaining after 10 min incubation[1]. | | IC 50 | H4 receptor: 19 nM (IC50) | | References | [1] Cramp S, et al. Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2516-9. DOI:10.1016/j.bmcl.2010.02.097 |
| | 8-chloro-2-methyl-4-(4-methylpiperazin-1-yl)-[1]benzofuro[3,2-d]pyrimidine Preparation Products And Raw materials |
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