13C C16 Sphingomyelin (d18:1/16:0)

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13C C16 Sphingomyelin (d18:1/16:0) Basic information
Product Name:13C C16 Sphingomyelin (d18:1/16:0)
Synonyms:13C C16 Sphingomyelin (d18:1/16:0);C16 Sphingomyelin-13C (d18:1/16:0-13C);R-[R*,S*-(E)]]-4-hydroxy-7-(1-hydroxy-2-hexadecenyl)-N,N,N-trimethyl-9-oxo-3,5-dioxa-8-aza-4-phosphatetracosan-1-aminium-9-13C,4-oxide,innersalt
CAS:144236-99-7
MF:C39H79N2O6P
MW:704.037121
EINECS:
Product Categories:
Mol File:144236-99-7.mol
13C C16 Sphingomyelin (d18:1/16:0) Structure
13C C16 Sphingomyelin (d18:1/16:0) Chemical Properties
storage temp. Store at -20°C
solubility Chloroform: soluble; Ethanol: soluble; Methanol: soluble
form A solid
Safety Information
MSDS Information
13C C16 Sphingomyelin (d18:1/16:0) Usage And Synthesis
DescriptionC16 Sphingomyelin-13C (d18:1/16:0-13C) is intended for use as an internal standard for the quantification of C16sphingomyelin by GC- or LC-MS. C16 Sphingomyelin is a naturally occurring sphingolipid. Levels of C16 sphingomyelin are elevated in the prefrontal cortex and cerebellum in a rat model of diabetes induced by streptozotocin (STZ; ), as well as in the liver in mouse models of Niemann-Pick type C1 disease. Plasma levels of C16 sphingomyelin are decreased in patients with prostate cancer. Model membranes containing C16 sphingomyelin, 1-palmitoyl-2-oleoyl-sn-glycero-3-PC (POPC; ), and cholesterol have been used in the study of lipid raft dynamics and membrane organization. [Matreya, LLC. Catalog No. 2200]
UsesN-Palmitoyl-D-sphingomyelin-13C is a deuterated labeled N-Palmitoyl-D-sphingomyelin[1]. N-Palmitoyl-D-sphingomyelin (Sphingomyelin 16:0) (Compound SM-03) can be used for the synthesis of lipid nanoparticles[2].
References[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Dandan LING, et al. Lipid compounds and lipid nanoparticle compositions. Patent. WO2023056914.
13C C16 Sphingomyelin (d18:1/16:0) Preparation Products And Raw materials
Tag:13C C16 Sphingomyelin (d18:1/16:0)(144236-99-7) Related Product Information
3,5-Dioxa-8-aza-4-phosphadocosan-1-aminium, 4-hydroxy-7-[(1R,2E)-1-hydroxy-2-hexadecen-1-yl]-N,N,N-trimethyl-9-oxo-, inner salt, 4-oxide, (7S)- 3,5-Dioxa-8-aza-4-phosphadotriacont-23-en-1-aminium, 4-hydroxy-7-[(1R)-1-hydroxyhexadecyl]-N,N,N-trimethyl-9-oxo-, inner salt, 4-oxide, (7S,23Z)- 3,5-Dioxa-8-aza-4-phosphahexacosan-1-aminium, 4-hydroxy-7-[(1R)-1-hydroxyhexadecyl]-N,N,N-trimethyl-9-oxo-, inner salt, 4-oxide, (7S)- N-hexanoyl-D-erythro-sphingosylphosphorylcholine Hexadecanamide, N-[(1R,3E)-1-[(phosphonooxy)methyl]-3-heptadecen-1-yl]-, ammonium salt (1:1) C8 Ceramide-1-phosphate