| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:Dabigatran etexilate-d13
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
CHINA ISOTOPE CO., LIMITED
|
| Tel: |
02151600108 13062666369 |
| Email: |
info@isotopechem.com |
| Products Intro: |
Product Name:Dabigatran etexilate-d13
CAS:2749293-92-1
Purity:Purity: >=98% Package:1mg Remarks:CA18451
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:Dabigatran etexilate-d13
CAS:2749293-92-1
Purity:95% Package:500μg;1mg
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:Dabigatran etexilate-d13
|
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| | Dabigatran etexilate-d13 Basic information |
| Product Name: | Dabigatran etexilate-d13 | | Synonyms: | Dabigatran etexilate-d13;ethyl3-(2-(((4-(N-(((hexyl-d13)oxy)carbonyl)carbamimidoyl)phenyl)amino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate | | CAS: | 2749293-92-1 | | MF: | C34H28D13N7O5 | | MW: | 640.813343114 | | EINECS: | | | Product Categories: | | | Mol File: | 2749293-92-1.mol |  |
| | Dabigatran etexilate-d13 Chemical Properties |
| solubility | DMSO: 0.5 mg/ml@ 25 degrees C | | form | Solid | | color | White to off-white |
| | Dabigatran etexilate-d13 Usage And Synthesis |
| Uses | Dabigatran etexilate-d13 is the deuterium labeled Dabigatran etexilate. Dabigatran etexilate (BIBR 1048) is an orally active proagent of Dabigatran. Dabigatran etexilate has anticoagulant effects and is used for the prophylaxis of venousthromboembolism and stroke due to atrial fibrillation[1]. | | References | [1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Wienen W, et al. In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally activeprodrug, dabigatran etexilate. Thromb Haemost. 2007 Jul;98(1):155-62. PMID:17598008
[3] Blair HA, Keating GM. Dabigatran Etexilate: A Review in Nonvalvular Atrial Fibrillation. Drugs. 2017;77(3):331-344. DOI:10.1007/s40265-017-0699-z
[4] XIAO-ZHI YANG . Design, synthesis and antithrombotic evaluation of novel dabigatran prodrugs containing methyl ferulate[J]. Bioorganic & Medicinal Chemistry Letters, 2013, 23 7: Pages 2089-2092. DOI: 10.1016/j.bmcl.2013.01.126 |
| | Dabigatran etexilate-d13 Preparation Products And Raw materials |
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