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BGC 20-1531 (hydrochloride) manufacturers
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| | BGC 20-1531 (hydrochloride) Basic information |
| Product Name: | BGC 20-1531 (hydrochloride) | | Synonyms: | BGC 20-1531 (hydrochloride);AP 1531;BGC20-1531
(PGN-1531;4-[[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamide hydrochloride;AP-1531 hydrochloride;GTPL3380 hydrochloride;BGC201531 hydrochloride(1186532615 free base),BGC 20 1531 hydrochloride(1186532 61 5 free base) | | CAS: | 1962928-26-2 | | MF: | C26H25ClN2O6S | | MW: | 529 | | EINECS: | | | Product Categories: | | | Mol File: | 1962928-26-2.mol |  |
| | BGC 20-1531 (hydrochloride) Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 1 mg/ml; DMSO: 1 mg/ml | | form | A crystalline solid |
| | BGC 20-1531 (hydrochloride) Usage And Synthesis |
| Description | BGC 20-1531 is a potent and selective antagonist of the prostaglandin E2 (PGE2; ) receptor subtype 4 (EP4) with Ki values of 11.7, >10,000, and >10,000 nM for EP4, EP2, and EP3, respectively. It is selective for EP4, exhibiting <50% inhibition at 47 ion channels, cell-surface transporters, enzymes, and nuclear receptors at a concentration of 10 μM. BGC 20-1531 antagonizes PGE2-induced cAMP accumulation in a dose-dependent manner in HEK293 EBNA cells that stably express human EP4 receptors. It also reverses PGE2-induced vasorelaxation (Kb = 15.85 nM) in human middle cerebral and middle meningeal arterial rings. BGC 20-1531 prevents PGE2-induced increases in carotid blood flow and decreases in carotid resistance with an ID50 value of 5 mg/kg in dogs. | | Uses | BGC 20-1531 Hydrochloride, is a potent and selective EP4 antagonist, exhibiting <50% inhibition at 47 ion channels, cell-surface transporters, enzymes, and nuclear receptors at a concentration of 10 μM. It also Inhibits PGE2-induced vasodilation of middle cerebral and meningeal arterieshuman middle cerebral and middle meningeal arterial rings. | | storage | Desiccate at RT | | References | [1] KA MAUBACH. BGC20-1531, a novel, potent and selective prostanoid EP4 receptor antagonist: a putative new treatment for migraine headache[J]. British Journal of Pharmacology, 2009, 156 2: 316-327. DOI: 10.1111/j.1476-5381.2009.00027.x |
| | BGC 20-1531 (hydrochloride) Preparation Products And Raw materials |
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