EZ-482 manufacturers
- EZ-482
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- $149.00
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2026-04-22
- CAS:1016456-76-0
- Purity: 97.29%
- Supply Ability: 10g
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| Product Name: | EZ-482 | | Synonyms: | EZ-482;EZ482,EZ 482;1-Phthalazineacetamide, N-[5-[[(3-chlorophenyl)amino]sulfonyl]-2-hydroxyphenyl]-3,4-dihydro-3-methyl-4-oxo- | | CAS: | 1016456-76-0 | | MF: | C23H19ClN4O5S | | MW: | 498.94 | | EINECS: | | | Product Categories: | | | Mol File: | 1016456-76-0.mol |  |
| | EZ-482 Chemical Properties |
| density | 1.49±0.1 g/cm3(Predicted) | | pka | 6.69±0.50(Predicted) | | form | Solid | | color | White to off-white |
| | EZ-482 Usage And Synthesis |
| Uses | EZ-482, a novel ligand of apolipoprotein (apoE), binds to sites on apoE in the C-terminal domain with Kds of 5-10 μM for apoE3 and apoE4. EZ-482 binds to apoE4 by a unique N-terminal allosteric effect. EZ482 has the potential for Alzheimer’s diseas[1]. | | IC 50 | apoE | | References | [1] Tridib Mondal, et al. ApoE: In Vitro Studies of a Small Molecule Effector. Biochemistry. 2016 May 10;55(18):2613-21. DOI:10.1021/acs.biochem.6b00324 |
| | EZ-482 Preparation Products And Raw materials |
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