| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
marketing1@energy-chemical.com |
|
| | VPC-13566 Basic information |
| Product Name: | VPC-13566 | | Synonyms: | VPC-13566;VPC-13566 >=98% (HPLC);VPC 13566,VPC13566;Quinoline, 2-(7-methyl-1H-indol-3-yl)-;2-(7-Methyl-1H-indol-3-yl)quinoline;VPC-13566, 10 mM in DMSO | | CAS: | 218464-59-6 | | MF: | C18H14N2 | | MW: | 258.32 | | EINECS: | | | Product Categories: | | | Mol File: | 218464-59-6.mol |  |
| | VPC-13566 Chemical Properties |
| Boiling point | 490.8±33.0 °C(Predicted) | | density | 1.225±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 20mg/mL, clear | | form | powder | | pka | 15.92±0.30(Predicted) | | color | white to beige | | InChIKey | FPKBNOVQNMJTEJ-UHFFFAOYSA-N | | SMILES | CC1=CC=CC2=C1NC=C2C3=NC4=CC=CC=C4C=C3 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | VPC-13566 Usage And Synthesis |
| Uses | VPC-13566, a BF3-specific small molecule, is an androgen receptor (AR) inhibitor. VPC-13566 is effective in inhibiting AR transcriptional activity in vitro as well as the growth of AR-dependent PCa cell lines. VPC-13566 can be used as a chemical probe to help identify unknown AR partners.VPC-13566 can be used for the research of cancer. | | Biological Activity | VPC-13566 is Binding Function 3 (BF3)-specific inhibitor of the androgen receptor. VPC-13566 potently inhibits AR transcriptional activity by displacement of the BAG1L peptide from the BF3 pocket. VPC-13566 inhibits the growth of various prostate cancer cell lines including an enzalutamide-resistant cell line and inhibits the growth of AR-dependent prostate cancer xenograft in mice. | | References | [1] Lallous N, et al. Targeting Binding Function-3 of the Androgen Receptor Blocks Its Co-Chaperone Interactions, Nuclear Translocation, and Activation. Mol Cancer Ther. 2016 Dec;15(12):2936-2945. DOI:10.1158/1535-7163.MCT-16-0354 |
| | VPC-13566 Preparation Products And Raw materials |
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