| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
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| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
Product Name:CORM-401
CAS:1001015-18-4
Purity:大于98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
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| | CORM-401 Basic information |
| Product Name: | CORM-401 | | Synonyms: | CORM-401;1001015-18-4,CORM-401;CORM401,CORM 401;(OC-6-22)-Manganate(1-), tetracarbonyl[N-(dithiocarboxy-κS,κS')-N-methylglycinato(2-)]-, hydrogen (1:1);Hydrogen 4-[(carboxylatomethyl)(methyl)amino]-2,2,2,2-tetrakis(hydroxymethyl)-1λ3-thia-3λ3-thia-2-manganacyclobut-3-en-2-ylium-1-ide;(OC-6-22)-Manganate(1-), tetracarbonyl[N-(dithiocarboxy-κS,κS')-N-methylglycinato(2-)]-, hydrogen (1:1) | | CAS: | 1001015-18-4 | | MF: | C8H8MnNO6S2 | | MW: | 333.21 | | EINECS: | | | Product Categories: | | | Mol File: | 1001015-18-4.mol |  |
| | CORM-401 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO : 25 mg/mL(Need ultrasonic) | | form | Solid | | color | Light yellow to yellow | | SMILES | CN(CC(O)=O)C1=S=[Mn-4]([C+]=O)([C+]=O)([C+]=O)([C+]=O)S1 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | CORM-401 Usage And Synthesis |
| Uses | CORM-401 is an oxidant-sensitive CO-releasing molecule. CORM-401 induces NO increase in the regulation of endothelial calcium signalling. CORM-401 reduces TNF-α/CHX and H2O2-induced ROS production. CORM-401 uncouples mitochondrial respiration and inhibits glycolysis[1][2][3]. | | Biological Activity | CORM-401 (Mn(CO)4(S2CNMe(CH2CO2H))) is a manganese-containing carbon monoxide-releasing molecule (CORM) th at generates at least three molar equivalents of CO. Due to reversible binding of CO, CORM-401 is relatively stable in solution (0.33 mol eq of CO loss after 4 h in PBS; [CORM-401] = 1 mM at time zero), while increased CO release occurs in the presence of a CO receptor or a ligand to prevent the rebinding of CO (3.2 mol eq of CO transferred to iron with a t1/2 of 0.8 min in the presence of 44 μM myoglobin; [CORM-401] = 10 μM at time zero). CO administration by CORM-401 is reported to uncouple mitochondrial respiration and inhibit glycolysis in human endothelial cells (10-100 μM), and relax isolated r at aortic rings (25 μM) pre-contracted with phenylephrine. | | References | [1] Kaczara P, et al. CORM-401 induces calcium signalling, NO increase and activation of pentose phosphate pathway in endothelial cells. FEBS J. 2018 Apr;285(7):1346-1358. DOI:10.1111/febs.14411
[2] Babu D, et al. Differential Effects of CORM-2 and CORM-401 in Murine Intestinal Epithelial MODE-K Cells under Oxidative Stress. Front Pharmacol. 2017 Feb 8;8:31. DOI:10.3389/fphar.2017.00031
[3] Kaczara P, et al. Carbon monoxide released by CORM-401 uncouples mitochondrial respiration and inhibits glycolysis in endothelial cells: A role for mitoBKCa channels. Biochim Biophys Acta. 2015 Oct;1847(10):1297-309. DOI:10.1016/j.bbabio.2015.07.004 |
| | CORM-401 Preparation Products And Raw materials |
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