6-Fluoro-2-(2-methylphenyl)-1,2-benzisothiazol-3(2H)-one manufacturers
- Thr101
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- $2500.00
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2026-05-11
- CAS:727664-79-1
- Purity:
- Supply Ability: 10g
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| | 6-Fluoro-2-(2-methylphenyl)-1,2-benzisothiazol-3(2H)-one Basic information |
| Product Name: | 6-Fluoro-2-(2-methylphenyl)-1,2-benzisothiazol-3(2H)-one | | Synonyms: | 6-Fluoro-2-(2-methylphenyl)-1,2-benzisothiazol-3(2H)-one;1,2-Benzisothiazol-3(2H)-one, 6-fluoro-2-(2-methylphenyl)-;Thr101;6-fluoro-2-o-tolylbenzo[d] isothiazol-3(2H)-one;NOX Inhibitor VII, Thr101;6-Fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3-one | | CAS: | 727664-79-1 | | MF: | C14H10FNOS | | MW: | 259.3 | | EINECS: | | | Product Categories: | | | Mol File: | 727664-79-1.mol |  |
| | 6-Fluoro-2-(2-methylphenyl)-1,2-benzisothiazol-3(2H)-one Chemical Properties |
| Boiling point | 397.9±52.0 °C(Predicted) | | density | 1.363±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 50mg/mL | | form | Solid | | pka | -2.59±0.20(Predicted) | | color | Off-white to yellow | | InChIKey | BUIZTXXZBDUOCR-UHFFFAOYSA-N | | SMILES | Fc1cc2c(cc1)C(=O)N(S2)c3c(cccc3)C |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | 6-Fluoro-2-(2-methylphenyl)-1,2-benzisothiazol-3(2H)-one Usage And Synthesis |
| Description | Thr101, also known as NOX Inhibitor VII, is a dose-dependent inhibitor of HDAC1, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7, HDAC8, and HDAC9. Thr101 is also a NOX inhibitor. | | Uses | Thr101 is an inhibitor (IC50=2.9 μM) of phosphomannose isomerase (PMI).PMI can compete with phosphomannose mutase 2 (PMM2) for the binding site of Man-6-P and convert mannose-6-phosphate (Man-6-P) into fructose-6-phosphate (Fru-6-P) .Thr101 only specifically inhibits PMI and not PMM2. Thr101 can be used for research of congenital disorder of glycosylation type Ia (CDG-Ia)[1]. | | Definition | ChEBI: 6-fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3-one is a member of benzothiazoles. | | References | [1] Dahl R, et al. Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia. J Med Chem. 2011 May 26;54(10):3661-8. DOI:10.1021/jm101401a |
| | 6-Fluoro-2-(2-methylphenyl)-1,2-benzisothiazol-3(2H)-one Preparation Products And Raw materials |
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