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| | Tofacitinib Impurity 77 Basic information |
| Product Name: | Tofacitinib Impurity 77 | | Synonyms: | Tofatinib impurity;3-((3R,4R)-4-methyl-3-(methyl(6-oxo-6,7-dihydro-5H-pyrrolo[2,3-d] pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile;Tofacitinib metabolite-1;1-Piperidinepropanenitrile, 3-[(6,7-dihydro-6-oxo-5H-pyrrolo[2,3-d]pyrimidin-4-yl)methylamino]-4-methyl-β-oxo-, (3R,4R)-;Azilsartan medoxomil impurity322;Tofatinib Impurity 32;Tofatinib impurity 38 | | CAS: | 1640971-51-2 | | MF: | C16H20N6O2 | | MW: | 328.38 | | EINECS: | | | Product Categories: | | | Mol File: | 1640971-51-2.mol |  |
| | Tofacitinib Impurity 77 Chemical Properties |
| Boiling point | 640.4±55.0 °C(Predicted) | | density | 1.312±0.06 g/cm3(Predicted) | | storage temp. | 4°C, protect from light | | form | Solid | | pka | 6.05±0.60(Predicted) | | color | Light yellow to yellow |
| | Tofacitinib Impurity 77 Usage And Synthesis |
| Uses | Tofacitinib metabolite-1 is a metabolite of Tofacitinib, a JAK inhibitor. Tofacitinib metabolite-1 can be used in the pharmacokinetics and metabolism studies of tofacitinib[1][2]. | | References | [1] Martin E Dowty, et al. The Pharmacokinetics, Metabolism, and Clearance Mechanisms of Tofacitinib, a Janus Kinase Inhibitor, in Humans. Drug Metab Dispos. 2014 Apr;42(4):759-73. DOI:10.1124/dmd.113.054940
[2] Matthias Gehringer, et al. Novel Hinge-Binding Motifs for Janus Kinase 3 Inhibitors: A Comprehensive Structure-Activity Relationship Study on Tofacitinib Bioisosteres. ChemMedChem. 2014 Nov;9(11):2516-27. DOI:10.1002/cmdc.201402252 |
| | Tofacitinib Impurity 77 Preparation Products And Raw materials |
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