CSF1R-IN-1 manufacturers
- CSF1R-IN-1
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- $95.00
-
2026-07-14
- CAS:2095849-04-8
- Purity: 98.56%
- Supply Ability: 10g
- CSF1R-IN-1
-
- $95.00
-
2026-07-14
- CAS:2095849-04-8
- Purity: 98.56%
- Supply Ability: 10g
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| | CSF1R-IN-1 Basic information |
| Product Name: | CSF1R-IN-1 | | Synonyms: | CSF1R-IN-1;CSF1R-IN-22;3-Pyridinecarboxamide, 5-(1-methyl-1H-pyrazol-4-yl)-N-[2-methyl-5-[[3-(trifluoromethyl)benzoyl]amino]phenyl]-;5-(1-Methyl-1H-pyrazol-4-yl)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)nicotinamide;Inhibitor,inhibit,c-Fms,CSF1R IN 1,colony stimulating factor 1 receptor,CSF1RIN1,CSF-1R-IN-1,CSF1R,CSF-1R,CSF-1 receptor;CSF1R-IN-1, 10 mM in DMSO;5-(1-Methyl-1H-pyrazol-4-yl)-N-(2-methyl-5-(3-(trifluoromethyl)benzamido)phenyl)nicotinamide , CSF1R-IN-1 | | CAS: | 2095849-04-8 | | MF: | C25H20F3N5O2 | | MW: | 479.45 | | EINECS: | | | Product Categories: | | | Mol File: | 2095849-04-8.mol |  |
| | CSF1R-IN-1 Chemical Properties |
| Boiling point | 528.3±50.0 °C(Predicted) | | density | 1.34±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 11.58±0.70(Predicted) | | form | Solid | | color | White to off-white |
| | CSF1R-IN-1 Usage And Synthesis |
| Uses | CSF1R-IN-1 is a CSF1R inhibitor with an with an IC50 of 0.5 nM. | | in vivo | CSF1R-IN-1 has favorable pharmacokinetics when dosed orally to mice. It appears suitable for in vivo pharmacology testing in the appropriate preclinical tumor model to demonstrate proof of concept.[1]. | Animal Model: | Male CD-1 mice, 25-35 grams (8-11 weeks old)[1] | | Dosage: | 2 mg/kg IV or 10 mg/kg orally (Per Os) | | Administration: | i.v. or oral | | Result: | I.V.: Cmax=3.55, T1/2=0.87
P.O.: Cmax=4.6, T1/2=1.8, Bioavailability=64%
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| | References | [1] Ramachandran SA, et al. Design, synthesis and optimization of bis-amide derivatives as CSF1R inhibitors. Bioorg Med Chem Lett. 2017 May 15;27(10):2153-2160. DOI:10.1016/j.bmcl.2017.03.064 |
| | CSF1R-IN-1 Preparation Products And Raw materials |
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