PROTAC BET DEGRADER-2
| 中文名称 | PROTAC BET DEGRADER-2 |
|---|---|
| 中文同义词 | 化合物 PROTAC BET degrader-2 |
| 英文名称 | PROTAC BET degrader-2 |
| 英文同义词 | PROTAC BET degrader-2;9H-Pyrimido[4,5-b]indole-2-carboxamide, 4-[(3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-4-isoxazolyl)-N-[3-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]propyl]-6-methoxy-;4-[(3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-1,2-oxazol-4-yl)-N-{3-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]propyl}-6-methoxy-9H-pyrimido[4,5-b]indole-2-carboxamide;4-[(3-Cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-4-isoxazolyl)-N-[3-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]propyl]-6-methoxy-9H-pyrimido[4,5-b]indole-2-carboxamide |
| CAS号 | 2093388-33-9 |
| 分子式 | C41H42N10O6 |
| 分子量 | 770.84 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2093388-33-9.mol |
| 结构式 |  |
PROTAC BET DEGRADER-2 性质
| 密度 | 1.56±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | DMSO：50 mg/mL (64.86 mM)；水：< 0.1 mg/mL（不溶） |
| 形态 | 固体 |
| 酸度系数(pKa) | 10.73±0.40(Predicted) |
| 颜色 | 浅黄至黄色 |
PROTAC BET degrader-2 是一种强效的 溴域及末端外 (BET) 蛋白的降解剂，在 RS4;11 细胞中测得其对细胞生长的 IC50 值为 9.6 nM，并能实现肿瘤消退。
IC50: 9.6 nM (BET in the RS4;11 leukemia cell line).
PROTAC BET degrader-2 (compound 25) is a highly potent degrader of Bromodomain and Extra-Terminal (BET) proteins with an IC 50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-114228 | PROTAC BET degrader-2 | 2093388-33-9 | 1 mg | 2181元 |
| 2025/12/22 | HY-114228 | PROTAC BET DEGRADER-2 PROTAC BET degrader-2 | 2093388-33-9 | 5mg | 4800元 |