| Company Name: |
Sichuan Wei Keqi Biological Technology Co., Ltd.
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| Tel: |
028-81700200 18116577057 |
| Email: |
3003855609@qq.com |
| Products Intro: |
Product Name:PROTACBETdegrader-2
CAS:2093388-33-9
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；200mg；500mg；1g
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| Company Name: |
BioPharmaMatrix,Inc.
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| Tel: |
0510-86010668 |
| Email: |
sales@biopharmamatrix.com |
| Products Intro: |
CAS:2093388-33-9
Package:1g
|
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| | PROTAC BET degrader-2 Basic information |
| Product Name: | PROTAC BET degrader-2 | | Synonyms: | PROTAC BET degrader-2;9H-Pyrimido[4,5-b]indole-2-carboxamide, 4-[(3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-4-isoxazolyl)-N-[3-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1-oxo-1H-isoindol-4-yl]propyl]-6-methoxy-;4-[(3-cyclopropyl-1-ethyl-1H-pyrazol-5-yl)amino]-7-(3,5-dimethyl-1,2-oxazol-4-yl)-N-{3-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]propyl}-6-methoxy-9H-pyrimido[4,5-b]indole-2-carboxamide | | CAS: | 2093388-33-9 | | MF: | C41H42N10O6 | | MW: | 770.84 | | EINECS: | | | Product Categories: | | | Mol File: | 2093388-33-9.mol |  |
| | PROTAC BET degrader-2 Chemical Properties |
| density | 1.56±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 50 mg/mL (64.86 mM);Water : < 0.1 mg/mL (insoluble) | | form | Solid | | pka | 10.73±0.40(Predicted) | | color | Light yellow to yellow |
| | PROTAC BET degrader-2 Usage And Synthesis |
| Uses | PROTAC BET degrader-2 is a PROTAC connected by ligands for Cereblon and BET with an IC50 value of 9.6 nM in cell growth inhibition in the RS4;11 cells and capable of achieving tumor regression. | | References | [1] Zhou B, et al. Discovery of a Small-Molecule Degrader of Bromodomain and Extra-Terminal (BET) Proteins with Picomolar Cellular Potencies and Capable of Achieving Tumor Regression. J Med Chem. 2018 Jan 25;61(2):462-481. DOI:10.1021/acs.jmedchem.6b01816 |
| | PROTAC BET degrader-2 Preparation Products And Raw materials |
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