- 4-Aminoantipyrine
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2026-09-11
- CAS:83-07-8
- Min. Order: 1g
- Purity: 98.0%
- Supply Ability: 10kg/month
- Ampyrone
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- $118.00
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2026-08-30
- CAS:83-07-8
- Purity: 98.74%
- Supply Ability: 10g
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| | 4-Aminoantipyrine Basic information |
| Product Name: | 4-Aminoantipyrine | | Synonyms: | Metamizole EP Impurity B;4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one;Metamizole Sodium Impurity 2（Minocycline EP Impurity B）;4-aminoantipirine;4-Amine-2,3-dimethyl-lphenyl-5-pyrazolone-[5],Ampyrone;4-amino-1,2-dihydro-1,5-dimethyl-2-phenyl-3h-pyrazol-3-on;AKOS BBS-00007964;AMINOANTIPYRINE, 4- | | CAS: | 83-07-8 | | MF: | C11H13N3O | | MW: | 203.24 | | EINECS: | 201-452-3 | | Product Categories: | PYRAMIDON;Heterocycles, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;reagent;Heterocycles;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Drug bulk;Antibiotic Explorer;Pyridines, Pyrimidines, Purines and Pteredines | | Mol File: | 83-07-8.mol |  |
| | 4-Aminoantipyrine Chemical Properties |
| Melting point | 105-110 °C(lit.) | | Boiling point | 340 C | | density | 0.8 | | bulk density | 430kg/m3 | | refractive index | 1.4930 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | H2O: 0.1 g/mL, clear | | pka | pK1: 4.94(+1) (25°C) | | form | Powder or Crystals | | color | Yellow to yellow-brown | | PH | 7.1 (100g/l, H2O, 20℃)(slurry) | | Odor | Odorless | | Water Solubility | ca. 500 g/L (20 ºC) | | Merck | 14,591 | | BRN | 181635 | | Stability: | Stable. May be light sensitive. | | InChI | 1S/C11H13N3O/c1-8-10(12)11(15)14(13(8)2)9-6-4-3-5-7-9/h3-7H,12H2,1-2H3 | | InChIKey | RLFWWDJHLFCNIJ-UHFFFAOYSA-N | | SMILES | CN1N(c2ccccc2)C(=O)C(N)=C1C | | LogP | -0.257 (est) | | CAS DataBase Reference | 83-07-8(CAS DataBase Reference) | | NIST Chemistry Reference | Aminoantipyrene(83-07-8) | | EPA Substance Registry System | 4-Aminoantipyrene (83-07-8) |
| Hazard Codes | Xn | | Risk Statements | 22-36/37/38-20/21/22 | | Safety Statements | 26-36-36/37/39 | | WGK Germany | 3 | | RTECS | CD2480000 | | F | 8-9-23 | | Hazard Note | Harmful | | TSCA | TSCA listed | | HS Code | 29331190 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral | | Toxicity | LD50 orally in Rabbit: 1700 mg/kg |
| | 4-Aminoantipyrine Usage And Synthesis |
| Chemical Properties | It is an amber to pale yellow crystalline powder. It is soluble in water, benzene, and ethanol, and only slightly soluble in diethyl ether. | | Uses | 4-Aminoantipyrine is a metabolite of aminopyrine, having both analgesic and anti-inflammatory properties. It readily forms metal complexes due to its amino nitrogen, a strong coordination site.
4-aminoantipyrine forms Schiff bases when treated with aldehydes/ketones, which are used in chemosensing applications.
Coupling Reagent for Trinder's reagent in colorimetric hydrogen peroxide detectionassays.
Forms highly stable dyes by coupling with Trinder's reagent in presence of Peroxidase and H2O2. Therefore suitable for use in test strip and solution diagnostics. | | Application | 4-aminoantipyrine is the most widely used analytical reagent for the estimation of phenol. It is used as a reagent for glucose determination in the presence of peroxidase and phenol. It is also used as indicator for trace phenol determinations in water.
Phenolic compounds were determined by buffering the sample to a pH of 10.0 and adding 4-aminoantipyrine to produce a yellow or amber colored complex in the presence of ferricyanide ion. The colour is intensified through extraction of the complex into chloroform. Measurement of this colour quantitatively determines the phenol concentration of the sample. | | Definition | ChEBI: 4-aminoantipyrine is a pyrazolone, a member of the class of pyrazoles that is antipyrine substituted at C-4 by an amino group. It is a metabolite of aminopyrine and of metamizole. It has a role as a non-steroidal anti-inflammatory drug, a non-narcotic analgesic, an antirheumatic drug, a peripheral nervous system drug, an EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor, an antipyretic, a drug metabolite and a marine xenobiotic metabolite. It is a primary amino compound and a pyrazolone. It derives from an antipyrine. | | Preparation | synthesis of 4-aminoantipyrine: Antipyrine is nitrosated by sodium nitrite, reduced by ammonium bisulfite and ammonium sulfite, hydrolyzed by sulfuric acid, and finally neutralized with liquid ammonia to obtain 4-aminoantipyrine. | | General Description | 4-Aminoantipyrine forms heterocyclic Schiff bases, by reaction with various aldehydes and oximes. These Schiff bases form stable complexes with transition metals. | | Purification Methods | It crystallises from EtOH or EtOH/ether. [Beilstein 25 III/IV 3554.] |
| | 4-Aminoantipyrine Preparation Products And Raw materials |
| Raw materials | Sulfuric acid-->Sodium nitrite-->Ammonium bisulfite-->Antipyrine-->Starch paper-->2,3-dimethyl-4-nitroso-1-phenyl-3-pyrazolin-5-one | | Preparation Products | Aminopyrine-->1,2-dihydro-1,5-dimethyl-4-(methylamino)-2-phenyl-3H-pyrazol-3-one-->AMMONIUM ALGINATE-->N-(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)formamide-->Ramifenazone-->N-(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-3-methoxybenzamide-->2-Cyano-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-acetamide-->3-Chloro-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)propanamide-->Aminopropylon |
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