2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one manufacturers
- (2R/S)-6-PNG
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- $95.00
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2026-05-11
- CAS:68682-01-9
- Purity: 98.00%
- Supply Ability: 10g
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| | 2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one Basic information |
| Product Name: | 2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one | | Synonyms: | 2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one;6PNG;(2R/S)-6-PNG;Naringenin 6-Prenyl Racemate;(2R/S)6PNG,(2R/S) 6 PNG;4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-;(2R/S)-6-PNG, 10 mM in DMSO;5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-(3-methylbut-2-en-1-yl)chroman-4-one | | CAS: | 68682-01-9 | | MF: | C20H20O5 | | MW: | 340.37 | | EINECS: | | | Product Categories: | | | Mol File: | 68682-01-9.mol |  |
| | 2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one Chemical Properties |
| Melting point | 212-214 °C(Solv: methanol (67-56-1)) | | Boiling point | 604.2±55.0 °C(Predicted) | | density | 1.314±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | A solid | | pka | 8.06±0.40(Predicted) | | color | White to off-white | | Stability: | Light Sensitive | | Major Application | food and beverages | | InChI | 1S/C20H20O5/c1-11(2)3-8-14-15(22)9-18-19(20(14)24)16(23)10-17(25-18)12-4-6-13(21)7-5-12/h3-7,9,17,21-22,24H,8,10H2,1-2H3/t17-/m0/s1 | | InChIKey | YHWNASRGLKJRJJ-KRWDZBQOSA-N | | SMILES | OC1=C(C(CC(C2=CC=C(O)C=C2)O3)=O)C3=CC(O)=C1CC=C(C)C |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral |
| | 2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one Usage And Synthesis |
| Uses | 6-Prenyl-rac-naringenin is a natural product isolated from Cudrania tricuspidata root which showed growth inhibition against Escherichia coli, Staphylococcus aureus and Klebsiella pneumoniae. | | Definition | ChEBI: (S)-4',5,7-Trihydroxy-6-prenylflavanone is a member of flavanones. | | in vivo | (2R/S)-6-PNG (6-Prenylnaringenin; 10-30 mg/kg; i.p.; single dose; 15 min before Na2S) significantly reduced the Na2S-induced nociceptive behavior and/or referred hyperalgesia in onscious mice with intracolonic (i.col.) administration of Na2S, an H2S donor[1].
(2R/S)-6-PNG (30 mg/kg; i.p.) prevents the increased number of phosphorylated ERK-positive cells following i.col. Na2S in laminae I-II, V-VI and X to which the primary afferent neurons project, and the Na2S-induced increase in the phosphorylated ERK-positive cell number[1].
(2R/S)-6-PNG (0.01-1 and 0.1-10 nmol/paw; intraplantar administration) restores the mechanical allodynia induced by partial sciatic nerve ligation (PSNL) and by i.p. administration of Oxaliplatin (OHP) a, respectively, in a dose-dependent manner[1].
(2R/S)-6-PNG (20-30 mg/kg; i.p.) significantly reverses the PSNL-induced allodynia. (2R/S)-6-PNG (10-20 mg/kg; i.p.) significantly reverses the OHP-induced allodynia (5 mg/kg; i.p.; single dose)[1].
| | IC 50 | T-type calcium channel |
| | 2,3-Dihydro-5,7-dihydroxy-2-(4-hydroxyphenyl)-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one Preparation Products And Raw materials |
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