N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxybenzamide trifluoroacetate

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N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxybenzamide trifluoroacetate manufacturers

  • PSEM 89S TFA
  • PSEM 89S TFA pictures
  • $41.00
  • 2026-07-21
  • CAS:1336913-03-1
  • Purity: 99.98%
  • Supply Ability: 10g
N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxybenzamide trifluoroacetate Basic information
Product Name:N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxybenzamide trifluoroacetate
Synonyms:N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxybenzamide trifluoroacetate;PSEM 89S TFA;PSEM 89S;(S)-2,5-Dimethoxy-N-(quinuclidin-3-yl)benzamide 2,2,2-trifluoroacetate;PSEM 89S TFA,GlyR,Ion,inhibit,nAChR,channels,L141F,PSAM,Q79G,PSEM 89S,Nicotinic acetylcholine receptors,Inhibitor;PSEM 89S TFA, 10 mM in DMSO
CAS:1336913-03-1
MF:C18H23F3N2O5
MW:404.39
EINECS:
Product Categories:
Mol File:1336913-03-1.mol
N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxybenzamide trifluoroacetate Structure
N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxybenzamide trifluoroacetate Chemical Properties
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Soluble in DMSO
form Solid
color Off-white to light yellow
Safety Information
MSDS Information
N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxybenzamide trifluoroacetate Usage And Synthesis
UsesPSEM 89S TFA is a selective and brain penetrant agonists for the resulting ion channels. PSEM 89S TFA is orthogonally selective for Q79G and L141F, respectively[1].
in vivo

PSEM 89S strongly reduces photostimulation-evoked feeding in mice expressing PSAML141F,Y115F- glycine receptor (GlyR) (30 mg/kg) but not in mice expressing only channelrhodopsin-2 (ChR2) (50 mg/kg)[1].
PSEM 89S (30 mg/kg) shows good brain penetrance in mice after minimally invasive intraperitoneal administration[1].

Animal Model:Male Agrp-cre mice (3-6 weeks)[1]
Dosage:30 mg/kg
Administration:I.p. administration
Result:Almost completely suppressed fos (a marker of neuron activation) in ChR2-expressing neurons.
Animal Model:C57BL/6 mice[1]
Dosage:30 mg/kg (Pharmacokinetic Analysis)
Administration:I.p. administration
Result:Rised rapidly in serum and brain, and was mostly cleared from both compartments in 1 h.
storageStore at -20°C
References[1] Christopher JM, et, al. Chemical and genetic engineering of selective ion channel-ligand interactions. Science. 2011 Sep 2; 333(6047): 1292-6. DOI:10.1126/science.1206606
N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxybenzamide trifluoroacetate Preparation Products And Raw materials
Tag:N-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,5-dimethoxybenzamide trifluoroacetate(1336913-03-1) Related Product Information
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