FR-167356

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Company Name: BOC Sciences  
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Company Name: TargetMol Chemicals Inc.  
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Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
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Company Name: TargetMol Chemicals Inc.  
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Company Name: Shanghai Amole Biotechnology Co., Ltd.  
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FR-167356 manufacturers

  • FR-167356
  • FR-167356 pictures
  • $71.00
  • 2026-08-08
  • CAS:174185-16-1
  • Purity: 99.74%
  • Supply Ability: 10g
FR-167356 Basic information
Product Name:FR-167356
Synonyms:FR-167356;Benzamide, 2,6-dichloro-N-[3-(1-hydroxy-1-methylethyl)-2-methyl-7-benzofuranyl]-
CAS:174185-16-1
MF:C19H17Cl2NO3
MW:378.25
EINECS:
Product Categories:
Mol File:174185-16-1.mol
FR-167356 Structure
FR-167356 Chemical Properties
Boiling point 422.7±40.0 °C(Predicted)
density 1.385±0.06 g/cm3(Predicted)
pka11+-.0.43(Predicted)
Safety Information
MSDS Information
FR-167356 Usage And Synthesis
UsesFR-167356 is a potent, orally active and selective vacuolar ATPase inhibitor with IC50 values of 170, 220, 370, and 1200 nM for osteoclast plasma membranes, macrophage microsomes, renal brush border membranes, and liver lysosomal membranes, respectively. FR-167356 inhibits bone resorption and ovariectomy-induced bone loss[1].
in vivo

FR-167356 (200 mg/kg; p.o.; daily, for 10 days; male C57BL/6 mice with B16-F10 xenografts) inhibits tumor growth and reduces MMP9 expression[1].
FR-167356 (200 mg/kg; p.o.; daily, for 10 days; male C57BL/6 mice with B16-F10 xenografts) reduces bone metastasis compared to untreated group[1].

Animal Model:male C57BL/6 mice with B16-F10 xenografts[1]
Dosage:200 mg/kg
Administration:Oral administration; daily, for 10 days
Result:Reduced the expression of MMP9 and reduced bone metastasis.
References[1] Nishisho T, et, al. The a3 isoform vacuolar type H-ATPase promotes distant metastasis in the mouse B16 melanoma cells. Mol Cancer Res. 2011 Jul;9(7):845-55. DOI:10.1158/1541-7786.MCR-10-0449
[2] Niikura K, et, al. A vacuolar ATPase inhibitor, FR167356, prevents bone resorption in ovariectomized rats with high potency and specificity: potential for clinical application. J Bone Miner Res. 2005 Sep;20(9):1579-88. DOI:10.1359/JBMR.050517
FR-167356 Preparation Products And Raw materials
Tag:FR-167356(174185-16-1) Related Product Information
FR-167356 Pantoprazole Sodium Abscisic acid β-D-glucopyranosyl ester Hexadecyl[2-([p-methoxybenzyl]-2-pyrimidinylamino)ethyl]dimethyl-ammonium bromide DWP14012 hydrochloride caloxin 2A1