PROXYPHYLLINE manufacturers
- Proxyphylline
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- $31.00 / 1g
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2026-04-13
- CAS:603-00-9
- Min. Order:
- Purity: 99.79%
- Supply Ability: 10g
- PROXYPHYLLINE
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- $35.68 / 1kg
-
2023-11-25
- CAS:603-00-9
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 100kg
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| | PROXYPHYLLINE Basic information |
| | PROXYPHYLLINE Chemical Properties |
| Melting point | 134-136°C | | Boiling point | 487.2±51.0 °C(Predicted) | | density | 1.46±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMF: 10 mg/ml
DMSO: 10 mg/ml
Ethanol: 1 mg/mlPBS (pH 7.2): 1 mg/ml | | pka | 14.55±0.20(Predicted) | | form | Solid | | color | White to Off-White | | Water Solubility | 285.7g/L(temperature not stated) | | Merck | 14,7905 | | InChI | InChI=1S/C10H14N4O3/c1-6(15)4-14-5-11-8-7(14)9(16)13(3)10(17)12(8)2/h5-6,15H,4H2,1-3H3 | | InChIKey | KYHQZNGJUGFTGR-UHFFFAOYSA-N | | SMILES | N1(CC(O)C)C2=C(N(C)C(=O)N(C)C2=O)N=C1 | | CAS DataBase Reference | 603-00-9(CAS DataBase Reference) | | NIST Chemistry Reference | Proxyphylline(603-00-9) |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 36 | | WGK Germany | 3 | | RTECS | XH5907500 | | HS Code | 2939.59.0000 |
| | PROXYPHYLLINE Usage And Synthesis |
| Chemical Properties | White Solid | | Uses | A metabolite of Theophylline in human plasma. | | Definition | ChEBI: Proxyphylline is an oxopurine. | | Biological Activity | ki: 82 nm for bovine brain a1 adenosine receptorproxyphylline is an a1 adenosine receptor antagonist.the a1 adenosine receptor, the best characterized purinergic receptor family, can mediate responses via multiple pertussis toxin-sensitive gtp binding proteins to various different effectors. | | in vitro | previous study showed that proxyphylline could selectively antagonize a1 adenosine receptors versus a2 adenosine receptors (ki = 850 μm for platelets) [1]. | | in vivo | in a previous study, rats that were allodynic following the vincristine injections were randomly allocated into four groups. theoesberiven f (a combination of proxyphylline and melilotus extract) was administered to rats. results showed that the decreased paw withdrawal threshold induced by vincristine injection was increased by theoesberiven f treatment and the increased withdrawal frequency to cold stimuli was also reduced by theoesberiven f treatment [2]. | | Purification Methods | Crystallise it from EtOH, aqueous MeOH or EtOAc. Roth Archiv Pharmazie 292 234 1959, Zelnik et al. Bull Soc Chim Fr 1733 1956, Beilstein 26 III/IV 2366.] | | References | [1] BRUNS R F. Adenosine antagonism by purines, pteridines and benzopteridines in human fibroblasts[J]. Biochemical pharmacology, 1981, 30 4: Pages 325-333. DOI: 10.1016/0006-2952(81)90062-9
[2] KEISUKE TAKEDA . EFFECTS OF AMINOPHYLLINE, PROXYPHYLLINE AND A PROXYPHYLINE-MELILOTUS EXTRACT-RUTIN MIXTURE (THEOESBERIVEN) ON THE HEART AND THE CORONARY CIRCULATION[J]. Japanese journal of pharmacology, 1977, 27 5: Pages 709-720. DOI: 10.1254/jjp.27.709
[3] LUCYNA KORZYCKA Dorota G. Synthesis, pharmacological activity and nitric oxide generation by nitrate derivatives of theophylline.[J]. Journal of Pharmacy and Pharmacology, 2008, 60 5: 637-645. DOI: 10.1211/jpp.60.5.0010
[4] KNUT DALAKER Hans P. Effect of some drugs on thromboplastin activity in mouse trophoblast cells in vitro and in vivo[J]. Biochemical pharmacology, 1986, 35 20: Pages 3433-3439. DOI: 10.1016/0006-2952(86)90609-x |
| | PROXYPHYLLINE Preparation Products And Raw materials |
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