NS309 manufacturers
- NS309
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- $52.00 / 5mg
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2025-10-27
- CAS:18711-16-5
- Min. Order:
- Purity: 97.55%
- Supply Ability: 10g
- NS309
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- $0.00 / 1kg
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2025-04-04
- CAS:18711-16-5
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1Ton
- NS309
-
- $5.50 / 1KG
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2020-01-13
- CAS:18711-16-5
- Min. Order: 1KG
- Purity: 98%min
- Supply Ability: 1kg-100kg
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| Product Name: | NS309 | | Synonyms: | NS 309; NS-309;1H-Indole-2,3-dione,6,7-dichloro-, 3-oxiMe;6,7-Dichloroindole-2,3-dione 3-oxime;6,7-Dichloroisatin 3-oxime;6,7-Dichloro-3-(hydroxyiMino)indolin-2-one;NS309;NS 309;NS-309;6,7-Dichloro-1H-indole-2,3-dione3-oxime;(Z)-6,7-dichloro-3-(hydroxyimino)indolin-2-one | | CAS: | 18711-16-5 | | MF: | C8H4Cl2N2O2 | | MW: | 231.04 | | EINECS: | | | Product Categories: | | | Mol File: | 18711-16-5.mol |  |
| | NS309 Chemical Properties |
| Melting point | 190-192℃ | | storage temp. | 2-8°C | | solubility | DMSO: ~22 mg/mL | | form | solid | | color | yellow |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 2 |
| | NS309 Usage And Synthesis |
| Uses | NS 309 decreases rat detrusor smooth muscle membrane potential and phasic contractions by activating SK3 channels. | | Biological Activity | Positive modulator of small- and intermediate- conductance Ca 2+ -activated K + channels (SK and IK channels); increases Ca 2+ sensitivity. Displays no activity at BK channels. | | Biochem/physiol Actions | NS309 is a Ca2+-activated IK/SK potassium channel activator. | | in vivo | NS309 (2 mg/kg; i.p.) protects against SCI/R in rabbits[6].
| Animal Model: | Adult New Zealand white rabbits (2.5-3.0 kg)[6] | | Dosage: | 2 mg/kg | | Administration: | Intraperitoneal injection | | Result: | Significantly improved neurological outcome of SCI/R challenged rabbits. |
| | storage | +4°C |
| | NS309 Preparation Products And Raw materials |
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