富马酸单甲酯
| 中文名称 | 富马酸单甲酯 |
|---|---|
| 中文同义词 | 富马酸单甲酯;富马酸单甲酯, 97%+;富马酸单甲基酯;富马酸单甲酯 5G;MONOMETHYL FUMARATE英文同义词: (E)-2-BUTENEDIOIC ACID HYDROGEN 1-METHYL ESTER;富马酸单甲酯(CAS号:2756-87-8);富马酸单甲酯 标准品;(E)-4-甲氧基-4-氧代丁基-2-烯酸 |
| 英文名称 | Monomethyl fumarate |
| 英文同义词 | (E)-2-Butenedioic acid hydrogen 1-methyl ester;Fumaric acid hydrogen 1-methyl ester;Monomethyl trans-ethylene-1,2-dicarboxylate;Monomethyl fumarate;Methyl hydrogen fumarate;Fumaric acid monomethyl ester;mono-Methyl fumarate,Fumaric acid monomethyl ester, Methyl hydrogen fumarate;(2E)-4-Methoxy-4-oxobut-2-enoic acid |
| CAS号 | 2756-87-8 |
| 分子式 | C5H6O4 |
| 分子量 | 130.1 |
| EINECS号 | 220-412-6 |
| 相关类别 | 羰基化合物;酯;杂质对照品;原料;食品添加剂;杀菌防腐剂;防腐剂;有机中间体;有机化工原料;化工原料;其他原料;化工材料;助剂;有机化工 |
| Mol文件 | 2756-87-8.mol |
| 结构式 |  |
富马酸单甲酯 性质
| 熔点 | 144-145 °C (lit.) |
|---|---|
| 沸点 | 250.0±23.0 °C(Predicted) |
| 密度 | 1.37 g/cm3 |
| 储存条件 | 2-8°C |
| 溶解度 | 可溶于氯仿（少许）、DMSO（少许）、甲醇（少许） |
| 形态 | 固体 |
| 酸度系数(pKa) | 3.40±0.10(Predicted) |
| 颜色 | 米白色 |
| 最大波长(λmax) | 209nm(MeOH)(lit.) |
| InChI | InChI=1S/C5H6O4/c1-9-5(8)3-2-4(6)7/h2-3H,1H3,(H,6,7)/b3-2+ |
| InChIKey | NKHAVTQWNUWKEO-NSCUHMNNSA-N |
| SMILES | C(OC)(=O)/C=C/C(O)=O |
| CAS 数据库 | 2756-87-8(CAS DataBase Reference) |
| Target | Value |
|
GPR109A
() |
Monomethyl fumarate completely inhibits forskolin induced cAMP synthesis with an IC
50
of 70 nM. Monomethyl fumarate induces a dose-dependent Ca
2+
signal in GPR109A transfected cells with an EC
50
of 9.4 μM.
Monomethyl fumarate (25 μM; 24 hours) attenuates 7β-OHC-induced cytotoxicity: cell growth inhibition; decreased cell viability; mitochondrial dysfunction; and cell death induction.
A single dose of Monomethyl fumarate (50-100 mg/kg; IP) before light exposure prevents these morphologic changes (bright light exposure induced photoreceptor death) in a dose-dependent manner.
Monomethyl fumarate (100 mg/kg) reduces retinal inflammation and oxidative stress. Monomethyl fumarate significantly suppresses light-induced retinopathy (LIR) upregulated genes in the NFkB pathway including: Nlrp3, Casp1, Il-1β, and Tnf-α.
| Animal Model: | Albino BALB/c mice (male, 6 weeks old) |
| Dosage: | 50, 65, 75, 100 mg/kg |
| Administration: | IP |
| Result: | Prevented these morphologic changes (bright light exposure induced photoreceptor death) in a dose-dependent manner. |