Fz7-21 manufacturers
- Fz7-21
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- $68.00
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2026-07-21
- CAS:2247635-23-8
- Purity: 99.80%
- Supply Ability: 10g
- Fz7-21
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- $1.00
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2020-03-06
- CAS:2247635-23-8
- Min. Order: 1g
- Purity: ≥98%
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| Product Name: | Fz7-21 | | Synonyms: | Fz7-21;Ac-Leu-Pro-Ser-Asp-Asp-Leu-Glu-Phe-Trp-Cys-His-Val-Met-Tyr-NH2;(Ac)-LPSDDLEFWCHVMY-NH2;lipid-binding groove,FZD7,Wnt,Fz7 21,Wnt–β-catenin,Fz-7-21,conformation,FZD7 CRD,intestinal organoids,Fz7-21,Inhibitor,Fz721,inhibit | | CAS: | 2247635-23-8 | | MF: | C83H114N18O23S2 | | MW: | 1796.05 | | EINECS: | | | Product Categories: | | | Mol File: | 2247635-23-8.mol |  |
| | Fz7-21 Chemical Properties |
| Boiling point | 2088.7±65.0 °C(Predicted) | | density | 1.358±0.06 g/cm3(Predicted) | | pka | 4.15±0.10(Predicted) | | form | Solid | | color | White to off-white |
| | Fz7-21 Usage And Synthesis |
| Uses | Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) is a potent peptide antagonist of FZD7 receptors , selectively binds to FZD7 CRD subclass and alters the conformation of the CRD and the architecture of its lipid-binding groove. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs the function of FZD7 in Wnt–β-catenin signalling and stem cell function in intestinal organoids[1][2]. | | storage | -20°C | | References | [1] Nile AH, et, al. A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nat Chem Biol. 2018 Jun;14(6):582-590. DOI:10.1038/s41589-018-0035-2
[2] Larasati Y, et, al. Unlocking the Wnt pathway: Therapeutic potential of selective targeting FZD7 in cancer. Drug Discov Today. 2022 Mar;27(3):777-792. DOI:10.1016/j.drudis.2021.12.008 |
| | Fz7-21 Preparation Products And Raw materials |
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